Trial reportSocial cognitive and affective neuroscience2013
Increased anterior cingulate cortex and hippocampus activation in Complex PTSD during encoding of negative words.
Trial report in Social cognitive and affective neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Neuroimaging insights into the psychosocial impact of the COVID-19 pandemic: a systematic review.Translational psychiatry · 2025Pooled it
- Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.JAMA network open · 2023Pooled it
- Individuals with the post-traumatic stress disorder process emotions in subcortical regions irrespective of cognitive engagement: a meta-analysis of cognitive and emotional interface.Brain imaging and behavior · 2021Pooled it
- Emotional Memory in Post-traumatic Stress Disorder: A Systematic PRISMA Review of Controlled Studies.Frontiers in psychology · 2019Pooled it
- Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis.Scientific reports · 2016Pooled it
- PKCα is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors.Proceedings of the National Academy of Sciences of the United States of America · 2012Trial
- Biomarkers for complex post-traumatic stress disorder: translational and evolutionary perspectives.Frontiers in psychiatry · 2026Article
- Transcutaneous vagal nerve stimulation for the treatment of trauma- and stressor-related disorders: systematic review of randomised controlled studies.BJPsych open · 2025Review
- Enhanced cognitive control following neurofeedback therapy in chronic treatment-resistant PTSD among refugees: a feasibility study.Frontiers in psychiatry · 2025Article
- A cingulate-hippocampal circuit mediates early depressive-like behavior in the mouse model of Alzheimer disease.iScience · 2024Article
- Neuroanatomical and functional correlates in post-traumatic stress disorder: A narrative review.Ibrain · 2024Review
- The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder.Scientific reports · 2023Article
- Differentiated processing of emotional cues in adolescents and young adults with ICD-11 PTSD and complex PTSD after child abuse.Brain and behavior · 2023Article
- Neural correlates linking trauma and physical symptoms.Psychiatry research. Neuroimaging · 2022Article
- Aberrant orbitofrontal cortical activation interferes with encoding of Pavlovian fear conditioning.Frontiers in behavioral neuroscience · 2022Article
- Association of attention and memory biases for negative stimuli with post-traumatic stress disorder symptoms.Journal of anxiety disorders · 2022Article
- Complex PTSD and borderline personality disorder.Borderline personality disorder and emotion dysregulation · 2021Review
- Pelvic Pain Alters Functional Connectivity Between Anterior Cingulate Cortex and Hippocampus in Both Humans and a Rat Model.Frontiers in systems neuroscience · 2021Article
- Emotion regulation through bifocal processing of fear inducing and disgust inducing stimuli.BMC neuroscience · 2020Article
- Multi-voxel pattern analysis of amygdala functional connectivity at rest predicts variability in posttraumatic stress severity.Brain and behavior · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-traumatic stress disorder (PTSD) is associated with impaired memory performance coupled with functional changes in brain areas involved in declarative memory and emotion regulation. It is not yet clear how symptom severity and comorbidity affect neurocognitive functioning in PTSD. We performed a functional magnetic resonance imaging (fMRI) study with an emotional declarative memory task in 28 Complex PTSD patients with comorbid depressive and personality disorders, and 21 healthy non-trauma-exposed controls. In Complex PTSD patients--compared to controls--encoding of later remembered negative words vs baseline was associated with increased blood oxygenation level dependent (BOLD) response in the left ventral anterior cingulate cortex (ACC) and dorsal ACC extending to the dorsomedial prefrontal cortex (dmPFC) together with a trend for increased left hippocampus activation. Patients tended to commit more False Alarms to negative words compared to controls, which was associated with enhanced left ventrolateral prefrontal and orbitofrontal cortex (vlPFC/OFC) responses. Severity of child abuse was positively correlated with left ventral ACC activity and severity of depression with (para) hippocampal and ventral ACC activity. Presented results demonstrate functional abnormalities in Complex PTSD in the frontolimbic brain circuit also implicated in fear conditioning models, but generally in the opposite direction, which may be explained by severity of the trauma and severity of comorbid depression in Complex PTSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.