ArticleCerebral cortex (New York, N.Y. : 1991)2012
KCTD8 gene and brain growth in adverse intrauterine environment: a genome-wide association study.
Article in Cerebral cortex (New York, N.Y. : 1991), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
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- Genomic analyses in Cavalier King Charles spaniels identify loci associated with clinical signs of Chiari-like malformation and Syringomyelia.BMC veterinary research · 2025Article
- Genetic implication of GABAFrontiers in pharmacology · 2025Review
- Dissecting the Association between Gut Microbiota and Brain Structure Change Rate: A Two-Sample Bidirectional Mendelian Randomization Study.Nutrients · 2023Article
- KCTD8 and KCTD12 Facilitate Axonal Expression of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The genetic regulation of size variation in the transcriptome of the cerebrum in the chicken and its role in domestication and brain size evolution.BMC genomics · 2020Article
- The organizing principle of GABABasic & clinical pharmacology & toxicology · 2020Review
- Alteration of the Cortex Shape as a Proxy of White Matter Swelling in Severe Cerebral Small Vessel Disease.Frontiers in neurology · 2019Article
- Cohort Profile: The Saguenay Youth Study (SYS).International journal of epidemiology · 2017Article
- Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction.BMC medical genetics · 2017Article
- ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide.NeuroImage · 2017Review
- Multiple regression analysis of the craniofacial region of Chinese Han people using linear and angular measurements based on MRI.Forensic sciences research · 2017Article
- Novel genetic loci underlying human intracranial volume identified through genome-wide association.Nature neuroscience · 2016Article
- Genetics and brain morphology.Neuropsychology review · 2015Article
- Saguenay Youth Study: a multi-generational approach to studying virtual trajectories of the brain and cardio-metabolic health.Developmental cognitive neuroscience · 2015Article
- Article
- The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.Brain imaging and behavior · 2014Review
- Maternal smoking during pregnancy and fetal organ growth: a magnetic resonance imaging study.PloS one · 2013Article
- A comparative, developmental, and clinical perspective of neurobehavioral sexual dimorphisms.Frontiers in neuroscience · 2012Article
Corrections and comments
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Authors and funding
17 authors at 12 institutions in 4 countries.
Funding
Abstract
The most dramatic growth of the human brain occurs in utero and during the first 2 years of postnatal life. Genesis of the cerebral cortex involves cell proliferation, migration, and apoptosis, all of which may be influenced by prenatal environment. Here, we show that variation in KCTD8 (potassium channel tetramerization domain 8) is associated with brain size in female adolescents (rs716890, P = 5.40 × 10(-09)). Furthermore, we found that the KCTD8 locus interacts with prenatal exposure to maternal cigarette smoking vis-à-vis cortical area and cortical folding: In exposed girls only, the KCTD8 locus explains up to 21% of variance. Using head circumference as a proxy of brain size at 7 years of age, we have replicated this gene-environment interaction in an independent sample. We speculate that KCTD8 might modulate adverse effects of smoking during pregnancy on brain development via apoptosis triggered by low intracellular levels of potassium, possibly reducing the number of progenitor cells.
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