Evidence map›Paper›PMID 22156529›Full record

ArticleJournal of virology2012

The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism.

Jorge Vera-Otarola, Loretto Solis, Ricardo Soto-Rifo, Emiliano P Ricci, Karla Pino, Nicole D Tischler, Théophile Ohlmann, Jean-Luc Darlix, Marcelo López-Lastra

Abstract read
In one paragraph

Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Review
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  9. Review
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  11. The internal ribosome entry site of theJournal of virology · 2021
    Article
  12. A Look intoViruses · 2021
    Review
  13. Article
  14. Chloroquine, an Anti-Malaria Drug as Effective Prevention for Hantavirus Infections.Frontiers in cellular and infection microbiology · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jorge Vera-OtarolaLaboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Loretto Solis
Ricardo Soto-Rifo
Emiliano P Ricci
Karla Pino
Nicole D Tischler
Théophile Ohlmann
Jean-Luc Darlix
Marcelo López-Lastra

Funding

Andes virus transmission and pathogenesis in ChileU01AI045452 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MERTZ, GREGORY JAMES · 2010 to 2014
$2.7M
NIAID NIH HHS 2U01AI045452-11NIAID NIH HHS U01 AI045452
6 · The paper itself

Abstract

The small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein. In 4 out of 5 genera in the Bunyaviridae, the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show that Andes hantavirus (ANDV) SmRNA encodes an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV infection. Additionally, our results suggest that translation initiation from the NSs initiation codon is mediated by ribosomal subunits that have bypassed the upstream N protein initiation codon through a leaky scanning mechanism.

Indexed as

Peptide Chain Initiation, TranslationalCell LineGene Expression Regulation, ViralHantavirus InfectionsHumansOpen Reading FramesOrthohantavirusRNA, MessengerRNA, ViralViral Nonstructural ProteinsRNA, MessengerRNA, ViralViral Nonstructural Proteins

Identifiers

PMID22156529
PMCPMC3302399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.