ArticleDementia and geriatric cognitive disorders2011
Estrogen receptor-Beta variants are associated with increased risk of Alzheimer's disease in women with down syndrome.
Article in Dementia and geriatric cognitive disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome.JAMA network open · 2022Pooled it
- Estrogen receptor beta (ESR2) gene polymorphism and susceptibility to dementia.Acta neurologica Belgica · 2021Pooled it
- Association of Alzheimer's disease biomarkers with low premorbid intellectual functioning in a multi-ethnic community-dwelling cohort: A cross-sectional study of HABS-HD.Journal of Alzheimer's disease : JAD · 2025Article
- Unveiling Gene Interactions in Alzheimer's Disease by Integrating Genetic and Epigenetic Data with a Network-Based Approach.Epigenomes · 2024Article
- Repurposing of Tibolone in Alzheimer's Disease.Biomolecules · 2023Review
- The role ofPostepy dermatologii i alergologii · 2022Article
- The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer's Disease.Journal of clinical medicine · 2021Review
- Is heart disease a risk factor for low dementia test battery scores in older persons with Down syndrome? Exploratory, pilot study, and commentary.International journal of developmental disabilities · 2020Article
- Epidemiology of estrogen and dementia in women with Down syndrome.Free radical biology & medicine · 2018Review
- Polymorphisms in sex steroid receptors: From gene sequence to behavior.Frontiers in neuroendocrinology · 2017Review
- A Review of Biomarkers for Alzheimer's Disease in Down Syndrome.Neurology and therapy · 2017Review
- Estrogen receptor beta polymorphisms and cognitive performance in women: associations and modifications by genetic and environmental influences.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome.Biochimica et biophysica acta · 2016Review
- Estrogen receptor β in Alzheimer's disease: From mechanisms to therapeutics.Ageing research reviews · 2015Review
- Telomere shortening in Down syndrome patients--when does it start?DNA and cell biology · 2015Article
- Age effects on cortical thickness in young Down's syndrome subjects: a cross-sectional gender study.Neuroradiology · 2015Article
- Systematic review and evidence gap mapping of Alzheimer's disease biomarker studies in those with intellectual and developmental disability.Alzheimer's & dementia (Amsterdam, Netherlands)Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsGenetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). We examined the relation of polymorphisms in the gene for the estrogen receptor-beta (ESR2) to the risk of AD in women with Down syndrome.
methodsTwo hundred and forty-nine women with Down syndrome, 31-70 years of age and nondemented at baseline, were followed at 14- to 18-month intervals for 4 years. Women were genotyped for 13 single-nucleotide polymorphisms (SNPs) in the ESR2 gene, and their association with AD incidence was examined.
resultsAmong postmenopausal women, we found a 2-fold increase in the risk of AD for women carrying 1 or 2 copies of the minor allele at 3 SNPs in introns seven (rs17766755) and six (rs4365213 and rs12435857) and 1 SNP in intron eight (rs4986938) of ESR2.
conclusionThese findings support a role for estrogen and its major brain receptors in modulating susceptibility to AD in women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.