ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Discovery of functional gene variants associated with human longevity: opportunities and challenges.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed.
- Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing.Mechanisms of ageing and development · 2013Trial
- Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling inMolecules and cells · 2022Review
- Genetic signature of human longevity in PKC and NF-κB signaling.Aging cell · 2021Article
- Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO inGenes & development · 2018Article
- A Modified Healthy Aging Index and Its Association with Mortality: The National Health and Nutrition Examination Survey, 1999-2002.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Assortative Mating by Ethnicity in Longevous Families.Frontiers in genetics · 2017Article
- A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster.BMB reports · 2016Review
- FOXO3 and related transcription factors in development, aging, and exceptional longevity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Who are the Okinawans? Ancestry, genome diversity, and implications for the genetic study of human longevity from a geographically isolated population.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)".Age (Dordrecht, Netherlands) · 2014Article
- Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Article
- Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Within- and between-species study of extreme longevity--comments, commonalities, and goals.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Age is a major risk factor for many human diseases. Extremely long-lived individuals, such as centenarians, have managed to ward off age-related diseases and serve as human models to search for the genetic factors that influence longevity. The discovery of evolutionarily conserved pathways with major impact on life span in animal models has provided tantalizing opportunities to test the relevance of these pathways for human longevity. Here we specifically focus on the insulin/insulin-like growth factor-1 signaling as a prime candidate pathway. Coupled with the rapid advances in ultra high-throughput sequencing technologies, it is now feasible to comprehensively analyze all possible sequence variants in candidate genes segregating with a longevity phenotype and to investigate the functional consequences of the associated variants. A better understanding of the functional genes that affect healthy longevity in humans may lead to a rational basis for intervention strategies that can delay or prevent age-related diseases.
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