ArticlePsychosomatic medicine2012
Physiologic dysfunction scores and cognitive function test performance in U.S. adults.
Article in Psychosomatic medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Allostatic Load Measurement: A Systematic Review of Reviews, Database Inventory, and Considerations for Neighborhood Research.International journal of environmental research and public health · 2022Pooled it
- Shared biological pathways for frailty and cognitive impairment: A systematic review.Ageing research reviews · 2018Pooled it
- Multi-omics analysis highlights the link of aging-related cognitive decline with systemic inflammation and alterations of tissue-maintenance.bioRxiv : the preprint server for biology · 2025Article
- Cognitive performance in young adult women with a history of premature adrenarche.Pediatric research · 2025Article
- Association of Occupational and Leisure-Time Physical Activity With Allostatic Load.American journal of preventive medicine · 2024Article
- Household Food Security Status and Allostatic Load among United States Adults: National Health and Nutrition Examination Survey 2015-2020.The Journal of nutrition · 2024Article
- Associations of Allostatic Load with Level of and Change in Cognitive Function Among Middle-Aged and Older Hispanic/Latino Adults: The Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA).Journal of Alzheimer's disease : JAD · 2024Article
- Allostatic load scoring using item response theory.Comprehensive psychoneuroendocrinology · 2021Article
- Allostatic Load: Importance, Markers, and Score Determination in Minority and Disparity Populations.Journal of urban health : bulletin of the New York Academy of Medicine · 2019Article
- Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts.Journal of Alzheimer's disease : JAD · 2019Review
- Factors That Affect Results of Psychometric Tests to Identify Patients With Minimal Hepatic Encephalopathy.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018Article
- Construct validity and internal consistency reliability of the Loewenstein occupational therapy cognitive assessment (LOTCA).BMC psychiatry · 2018Article
- Variation in the Calculation of Allostatic Load Score: 21 Examples from NHANES.Journal of racial and ethnic health disparities · 2017Review
- The association of Toxoplasma gondii infection with neurocognitive deficits in a population-based analysis.Social psychiatry and psychiatric epidemiology · 2014Article
- Biological correlates of adult cognition: midlife in the United States (MIDUS).Neurobiology of aging · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo investigate the relationship between a measure of cumulative physiologic dysfunction and specific domains of cognitive function.
methodsWe examined a summary score measuring physiologic dysfunction, a multisystem measure of the body's ability to effectively adapt to physical and psychological demands, in relation to cognitive function deficits in a population of 4511 adults aged 20 to 59 who participated in the Third National Health and Nutrition Examination Survey (1988-1994). Measures of cognitive function comprised three domains: working memory, visuomotor speed, and perceptual-motor speed. "Physiologic dysfunction" scores summarizing measures of cardiovascular, immunologic, kidney, and liver functions were explored. We used multiple linear regression models to estimate associations between cognitive function measures and physiologic dysfunction scores, adjusting for socioeconomic factors, test conditions, and self-reported health factors.
resultsWe noted a dose-response relationship between physiologic dysfunction and working memory (coefficient = 0.207, 95% confidence interval = 0.066-0.348, p < .0001), which persisted after adjustment for all covariates (p = .03). We did not observe any significant relationships between dysfunction scores and visuomotor (p = .37) or perceptual-motor ability (p = .33).
conclusionsOur findings suggest that multisystem physiologic dysfunction is associated with working memory. Future longitudinal studies are needed to clarify the underlying mechanisms and explore the persistency of this association into later life. We suggest that such studies should incorporate physiologic data, neuroendocrine parameters, and a wide range of specific cognitive domains.
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