ArticleAntimicrobial agents and chemotherapy2012
Characterization of nasal and blood culture isolates of methicillin-resistant Staphylococcus aureus from patients in United States Hospitals.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- Chlorhexidine and Mupirocin Susceptibility of Methicillin-Resistant Staphylococcus aureus Isolates in the REDUCE-MRSA Trial.Journal of clinical microbiology · 2016Trial
- Mupirocin and chlorhexidine resistance in Staphylococcus aureus in patients with community-onset skin and soft tissue infections.Antimicrobial agents and chemotherapy · 2013Trial
- Characterization of methicillin-resistant Staphylococcus aureus strains recovered from a phase IV clinical trial for linezolid versus vancomycin for treatment of nosocomial pneumonia.Journal of clinical microbiology · 2012Trial
- Chlorhexidine gluconate reduces transmission of methicillin-resistant Staphylococcus aureus USA300 among Marine recruits.Infection control and hospital epidemiology · 2012Trial
- Genomic diversity and topical antimicrobial resistance inAntimicrobial agents and chemotherapy · 2026Article
- Epidemiologic and Clinical Divergence of MRSA USA100 and USA300 in the United States.Antibiotics (Basel, Switzerland) · 2026Article
- Antivirulence Properties of Kuraridin Against Methicillin-ResistantBiomedicines · 2025Article
- Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) harboring mupirocin and biocide resistance genes in a large health care system.American journal of infection control · 2025Article
- A stable systemic infection of methicillin-resistantFrontiers in microbiology · 2025Article
- Antimicrobial Resistance Patterns of Outpatient Staphylococcus aureus Isolates.JAMA network open · 2024Article
- Whole genome sequencing and molecular epidemiology of methicillin-resistant Staphylococcus aureus isolated from patients with bacteraemia in Slovenia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation.Cell host & microbe · 2023Article
- Prevalence, Infectious Characteristics and Genetic Diversity ofPathogens (Basel, Switzerland) · 2022Article
- Bacterial genotype and clinical outcomes in solid organ transplant recipients with Staphylococcus aureus bacteremia.Transplant infectious disease : an official journal of the Transplantation Society · 2021Article
- Genomic Update of Phenotypic Prediction Rule for Methicillin-Resistant Staphylococcus aureus (MRSA) USA300 Discloses Jail Transmission Networks with Increased Resistance.Microbiology spectrum · 2021Article
- A global transcriptomic analysis ofMicrobial genomics · 2021Article
- Biographical Feature: Fred C. Tenover, Ph.D., D(ABMM), F(AAM), FIDSA.Journal of clinical microbiology · 2021Article
- Genetic analysis of methicillin-susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug-resistant ST239 with strong biofilm-production ability.Journal of clinical laboratory analysis · 2020Article
- Antagonistic Effect of Colistin on Vancomycin Activity against Methicillin-Resistant Staphylococcus aureus inAntimicrobial agents and chemotherapy · 2020Article
- The prevalence and molecular mechanisms of mupirocin resistance in Staphylococcus aureus isolates from a Hospital in Cape Town, South Africa.Antimicrobial resistance and infection control · 2020Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
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Abstract
A total of 299 nares and 194 blood isolates of methicillin-resistant Staphylococcus aureus (MRSA), each recovered from a unique patient, were collected from 23 U.S. hospitals from May 2009 to March 2010. All isolates underwent spa and staphylococcal cassette chromosome mec element (SCCmec) typing and antimicrobial susceptibility testing; a subset of 84 isolates was typed by pulsed-field gel electrophoresis (PFGE) using SmaI. Seventy-six spa types were observed among the isolates. Overall, for nasal isolates, spa type t002-SCCmec type II (USA100) was the most common strain type (37% of isolates), while among blood isolates, spa type t008-SCCmec type IV (USA300) was the most common (39%). However, the proportion of all USA100 and USA300 isolates varied by United States census region. Nasal isolates were more resistant to tobramycin and clindamycin than blood isolates (55.9% and 48.8% of isolates versus 36.6% and 39.7%, respectively; for both, P < 0.05). The USA300 isolates were largely resistant to fluoroquinolones. High-level mupirocin resistance was low among all spa types (<5%). SCCmec types III and VIII, which are rare in the United States, were observed along with several unusual PFGE types, including CMRSA9, EMRSA15, and the PFGE profile associated with sequence type 239 (ST239) isolates. Typing data from this convenience sample suggest that in U.S. hospitalized patients, USA100 isolates of multiple spa types, while still common in the nares, have been replaced by USA300 isolates as the predominant MRSA strain type in positive blood cultures.
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