Evidence map›Paper›PMID 22154944›Full record

ReviewCurrent opinion in cell biology2012

Structural organization of the kinetochore-microtubule interface.

Jennifer G DeLuca, Andrea Musacchio

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. Structure and function of the outer kinetochore.Nature reviews. Molecular cell biology · 2026
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jennifer G DeLucaDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, United States. jennifer.deluca@colostate.edu
Andrea Musacchio

Funding

Kinetochore Function in Vertebrate CellsR01GM088371 · NIGMS · COLORADO STATE UNIVERSITY · PI DELUCA, JENNIFER G · 2010 to 2018
$3.1M
The Kinetochore-Microtubule Interface in Vertebrate CellsK01CA125051 · NCI · COLORADO STATE UNIVERSITY · PI DELUCA, JENNIFER G · 2007 to 2011
$650k
NCI NIH HHS K01 CA125051NCI NIH HHS K01CA125051NIGMS NIH HHS GM088371NIGMS NIH HHS R01 GM088371
6 · The paper itself

Abstract

Successful mitosis depends on the stable, yet regulated attachment of chromosomes to spindle microtubules. The kinetochore, a large macromolecular structure assembled at sites of centromeric heterochromatin, is responsible for generating and regulating these essential attachments. Over the last several years, concerted experimental efforts have brought the structural view of the kinetochore-microtubule interface more clearly into focus. Here, we review important recent advancements and discuss several unresolved questions regarding how kinetochores dynamically bridge mitotic chromosomes to spindle microtubules.

Indexed as

AnimalsChromosomesHumansKinetochoresMicrotubulesMitosisSpindle Apparatus

Identifiers

PMID22154944
PMCPMC3294040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.