ArticleNeurobiology of aging2012
Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Sex Differences in Astrocyte Activity.Cells · 2024Review
- Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant.Translational stroke research · 2022Article
- Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?Frontiers in cellular neuroscience · 2021Review
- Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells.Frontiers in cellular neuroscience · 2020Article
- Current Strategies for Brain Drug Delivery.Theranostics · 2018Review
- Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury.Progress in neurobiology · 2017Review
- Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease.American journal of physiology. Heart and circulatory physiology · 2017Review
- Article
- Pannexin1 knockout and blockade reduces ischemic stroke injury in female, but not in male mice.Oncotarget · 2017Article
- Astrocytic response to cerebral ischemia is influenced by sex differences and impaired by aging.Neurobiology of disease · 2016Review
- Effect of sex and age interactions on functional outcome after stroke.CNS neuroscience & therapeutics · 2015Review
- Histone methylation patterns in astrocytes are influenced by age following ischemia.Epigenetics · 2015Article
- Estrogen-IGF-1 interactions in neuroprotection: ischemic stroke as a case study.Frontiers in neuroendocrinology · 2015Review
- Blood brain barrier and neuroinflammation are critical targets of IGF-1-mediated neuroprotection in stroke for middle-aged female rats.PloS one · 2014Article
- All's well that transcribes well: non-coding RNAs and post-stroke brain damage.Neurochemistry international · 2013Review
- Age-related changes in brain support cells: Implications for stroke severity.Neurochemistry international · 2013Review
- Cerebral ischemic stroke: is gender important?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Review
- The effects of estrogen in ischemic stroke.Translational stroke research · 2013Review
- Neuroprotection for ischemic stroke: moving past shortcomings and identifying promising directions.International journal of molecular sciences · 2013Review
- Characterization of adult rat astrocyte cultures.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In middle-aged female rats, focal ischemia leads to a larger cortical infarction as compared with younger females. To determine if stroke-induced cytotoxicity in middle-aged females was associated with impaired astrocyte function, astrocytes were harvested and cultured from the ischemic cortex of young and middle-aged female rats. Middle-aged astrocytes cleared significantly less glutamate from media as compared with young female astrocytes. Furthermore, astrocyte-conditioned media from middle-aged female astrocytes induced greater migration of peripheral blood monocyte cells (PBMCs) and expressed higher levels of the chemoattractant macrophage inflammatory protein-1 (MIP-1). Middle-aged astrocytes also induced greater migration of neural progenitor cells (NPCs), however, their ability to promote neuronal differentiation of neural progenitor cells was similar to young astrocytes. In males, where cortical infarct volume is similar in young and middle-aged animals, no age-related impairment was observed in astrocyte function. These studies show that the aging astrocyte may directly contribute to infarct severity by inefficient glutamate clearance and enhanced cytokine production and suggest a cellular target for improved stroke therapy among older females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.