ArticleSchizophrenia research2012
Spatial memory deficits in a virtual reality eight-arm radial maze in schizophrenia.
Article in Schizophrenia research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of transcranial magnetic stimulation on spatial memory: a systematic review across animal and human studies.Frontiers in behavioral neuroscience · 2026Pooled it
- Current limitations in technology-based cognitive assessment for severe mental illnesses: a focus on feasibility, reliability, and ecological validity.Frontiers in behavioral neuroscience · 2025Review
- Using virtual reality to improve verbal episodic memory in schizophrenia: A proof-of-concept trial.Schizophrenia research. Cognition · 2024Article
- Application of Real and Virtual Radial Arm Maze Task in Human.Brain sciences · 2022Review
- Does global positioning system-based navigation dependency make your sense of direction poor? A psychological assessment and eye-tracking study.Frontiers in psychology · 2022Article
- The effect of schizotypy on spatial learning in an environment with a distinctive shape.Frontiers in psychology · 2022Article
- Verification of using virtual reality to evaluate deficiencies in cognitive function among patients with schizophrenia in the remission stage: a cross-sectional study.BMC psychiatry · 2021Article
- Cross-species neuroscience: closing the explanatory gap.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Metabolite Alterations in Adults With Schizophrenia, First Degree Relatives, and Healthy Controls: A Multi-Region 7T MRS Study.Frontiers in psychiatry · 2021Article
- Virtual reality as a clinical tool in mental health research and practice .Dialogues in clinical neuroscience · 2020Review
- Assessing Cognition Outside of the Clinic: Smartphones and Sensors for Cognitive Assessment Across Diverse Psychiatric Disorders.The Psychiatric clinics of North America · 2019Review
- Spatial Learning and Memory Using a Radial Arm Maze with a Head-Mounted Display.Psychiatry investigation · 2018Article
- EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment.PLoS pathogens · 2018Article
- Regulation of sustained attention, false alarm responding and implementation of conditional rules by prefrontal GABAPsychopharmacology · 2017Article
- Virtual Reality Objectifies the Diagnosis of Psychiatric Disorders: A Literature Review.Frontiers in psychiatry · 2017Review
- Effectiveness of fast mapping to promote learning in schizophrenia.Schizophrenia research. Cognition · 2016Article
- Modeling neurodevelopmental cognitive deficits in tasks with cross-species translational validity.Genes, brain, and behavior · 2016Review
- Hippocampal-dorsolateral prefrontal coupling as a species-conserved cognitive mechanism: a human translational imaging study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Developing treatments for cognitive deficits in schizophrenia: the challenge of translation.Journal of psychopharmacology (Oxford, England) · 2015Review
- Selective overexpression of dopamine D3 receptors in the striatum disrupts motivation but not cognition.Biological psychiatry · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Learning and memory impairments are present in schizophrenia (SZ) throughout the illness course and predict psychosocial function. Abnormalities in prefrontal and hippocampal function are thought to contribute to SZ deficits. The radial arm maze (RAM) is a test of spatial learning and memory in rodents that relies on intact prefrontal and hippocampal function. The goal of the present study was to investigate spatial learning in SZ using a virtual RAM. Thirty-three subjects with SZ and thirty-nine healthy controls (HC) performed ten trials of a virtual RAM task. Subjects attempted to learn to retrieve four rewards each located in separate arms. As expected, subjects with SZ used more time and traveled more distance to retrieve rewards, made more reference (RM) and working memory (WM) errors, and retrieved fewer rewards than HC. It is important to note that the SZ group did learn but did not reach the level of HC. Whereas RM errors decreased across trials in the SZ group, WM errors did not. There were no significant relationships between psychiatric symptom severity and maze performance. To our knowledge, use of a virtual 8-arm radial maze task in SZ to assess spatial learning is novel. Impaired virtual RAM performance in SZ is consistent with studies that examined RAM performance in animal models of SZ. Results provide further support for compromised prefrontal and hippocampal function underlying WM and RM deficits in SZ. The virtual RAM task could help bridge preclinical and clinical research for testing novel drug treatments of SZ.
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