ArticleRespiratory physiology & neurobiology2012
Persistence of the nasotrigeminal reflex after pontomedullary transection.
Article in Respiratory physiology & neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 21 citations in OpenAlex.
- A projection atlas of excitatory and inhibitory inputs to the preBötzinger complex: substrates for multimodal breathing control.Journal of neurophysiology · 2026Article
- Lactate increases oxygen unloading of preconditioned blood from male elite breath-hold divers.Physiological reports · 2026Article
- Plasticity induced loss of apnea alarm through repeated apneas: A proposed mechanism for respiratory sudden death.Epilepsy & behavior : E&B · 2025Review
- A brainstem circuit for the expression of defensive facial reactions in rat.Current biology : CB · 2023Article
- The Mammalian Diving Response: Inroads to Its Neural Control.Frontiers in neuroscience · 2020Review
- Diving Response in Rats: Role of the Subthalamic Vasodilator Area.Frontiers in neurology · 2016Article
- Repetitive Diving in Trained Rats Still Increases Fos Production in Brainstem Neurons after Bilateral Sectioning of the Anterior Ethmoidal Nerve.Frontiers in physiology · 2016Article
- The trigeminocardiac reflex - a comparison with the diving reflex in humans.Archives of medical science : AMS · 2015Article
- The mammalian diving response: an enigmatic reflex to preserve life?Physiology (Bethesda, Md.) · 2013Review
- Chemosensors in the nose: guardians of the airways.Physiology (Bethesda, Md.) · 2013Review
- Activation of brainstem neurons by underwater diving in the rat.Frontiers in physiology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Most behaviors have numerous components based on reflexes, but the neural circuits driving most reflexes rarely are documented. The nasotrigeminal reflex induced by stimulating the nasal mucosa causes an apnea, a bradycardia, and variable changes in mean arterial blood pressure (MABP). In this study we tested the nasotrigeminal reflex after transecting the brainstem at the pontomedullary junction. The nasal mucosae of anesthetized rats were stimulated with ammonia vapors and their brainstems then were transected. Complete transections alone induced an increase in resting heart rate (HR; p<0.001) and MABP (p<0.001), but no significant change in ventilation. However, the responses to nasal stimulation after transection were similar to those seen prior to transection. HR still dropped significantly (p<0.001), duration of apnea remained the same, as did changes in MABP. Results from rats whose transection were incomplete are discussed. These data implicate that the neuronal circuitry driving the nasotrigeminal reflex, and indirectly the diving response, is intrinsic to the medulla and spinal cord.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.