ReviewGeneral and comparative endocrinology2012
Rapid steroid hormone actions initiated at the cell surface and the receptors that mediate them with an emphasis on recent progress in fish models.
Review in General and comparative endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 157 citations in OpenAlex.
- Progestogen is a potential trigger initiating sex inversion in rice field eel (Monopterus albus).Fish physiology and biochemistry · 2025Article
- Effects of progestogen neurosteroids on locomotor activity in zebrafish embryos and larvae.Fish physiology and biochemistry · 2025Article
- Article
- Expression of novel androgen receptors in three GnRH neuron subtypes in the cichlid brain.Journal of neuroendocrinology · 2024Article
- Progesterone induces meiosis through two obligate co-receptors with PLA2 activity.bioRxiv : the preprint server for biology · 2024Article
- Expression of novel androgen receptors in three GnRH neuron subtypes in the cichlid brain.bioRxiv : the preprint server for biology · 2024Article
- Pheromone Perception in Fish: Mechanisms and Modulation by Internal Status.Integrative and comparative biology · 2023Review
- Membrane Progesterone Receptors (mPRs/PAQRs) Are Going beyond Its Initial Definitions.Membranes · 2023Review
- Membrane Progesterone Receptors (mPRs, PAQRs): Review of Structural and Signaling Characteristics.Cells · 2022Review
- Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Membrane progesterone receptor α (mPRα) enhances hypoxia-induced vascular endothelial growth factor secretion and angiogenesis in lung adenocarcinoma through STAT3 signaling.Journal of translational medicine · 2022Article
- Estrogenic Modulation of Retinal Sensitivity in Reproductive Female Túngara Frogs.Integrative and comparative biology · 2021Article
- The Crossroads between Zinc and Steroidal Implant-Induced Growth of Beef Cattle.Animals : an open access journal from MDPI · 2021Review
- Fish reproductive biology - Reflecting on five decades of fundamental and translational research.General and comparative endocrinology · 2021Review
- Azole pharmaceuticals induce germinal vesicle breakdown (GVBD) in preovulatory oocytes of zebrafish (Danio rerio): an in vitro study.Environmental science and pollution research international · 2021Article
- G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone.Cell communication and signaling : CCS · 2020Review
- Impaired oocyte maturation and ovulation in membrane progestin receptor (mPR) knockouts in zebrafish.Molecular and cellular endocrinology · 2020Article
- Review
- Twenty years of transcriptomics, 17alpha-ethinylestradiol, and fish.General and comparative endocrinology · 2020Review
- Seasonal Related Multifactorial Control of Pituitary Gonadotropin and Growth Hormone in Female Goldfish: Influences of Neuropeptides and Thyroid Hormone.Frontiers in endocrinology · 2020Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
In addition to the classic genomic mechanism of steroid action mediated by activation of intracellular nuclear receptors, there is now extensive evidence that steroids also activate receptors on the cell surface to initiate rapid intracellular signaling and biological responses that are often nongenomic. Recent progress in our understanding of rapid, cell surface-initiated actions of estrogens, progestins, androgens and corticosteroids and the identities of the membrane receptors that act as their intermediaries is briefly reviewed with a special emphasis on studies in teleost fish. Two recently discovered novel proteins with seven-transmembrane domains, G protein-coupled receptor 30 (GPR30), and membrane progestin receptors (mPRs) have the ligand binding and signaling characteristics of estrogen and progestin membrane receptors, respectively, but their functional significance is disputed by some researchers. GPR30 is expressed on the cell surface of fish oocytes and mediates estrogen inhibition of oocyte maturation. mPRα is also expressed on the oocyte cell surface and is the intermediary in progestin induction of oocyte maturation in fish. Recent results suggest there is cross-talk between these two hormonal pathways and that there is reciprocal down-regulation of GPR30 and mPRα expression by estrogens and progestins at different phases of oocyte development to regulate the onset of oocyte maturation. There is also evidence in fish that mPRs are involved in progestin induction of sperm hypermotility and anti-apoptotic actions in ovarian follicle cells. Nonclassical androgen and corticosteroid actions have also been described in fish models but the membrane receptors mediating these actions have not been identified.
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