ArticlePsychoneuroendocrinology2012
Cumulative stress and maternal prenatal corticotropin-releasing hormone in an urban U.S. cohort.
Article in Psychoneuroendocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00269256 (Stress, Environment, and Genetics in Urban Asthma), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stress, Environment, and Genetics in Urban Asthma
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Systematic Review of Chronic Discrimination and Changes in Biology During Pregnancy Among African American Women.Journal of racial and ethnic health disparities · 2019Pooled it
- Discrimination and the HPA axis: current evidence and future directions.Journal of behavioral medicine · 2017Pooled it
- The contribution of racism-related stress and adversity to disparities in birth outcomes: evidence and research recommendations.F&S reports · 2022Article
- Maternal exposure to childhood traumatic events, but not multi-domain psychosocial stressors, predict placental corticotrophin releasing hormone across pregnancy.Social science & medicine (1982) · 2020Article
- A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors-implications for research on perinatal outcomes in the ECHO program.Journal of perinatology : official journal of the California Perinatal Association · 2020Review
- Prenatal maternal stress and birth outcomes in rural Ghana: sex-specific associations.BMC pregnancy and childbirth · 2019Article
- Associations among maternal socioeconomic status in childhood and pregnancy and hair cortisol in pregnancy.Psychoneuroendocrinology · 2019Article
- Evidence establishing a link between prenatal and early-life stress and asthma development.Current opinion in allergy and clinical immunology · 2018Review
- Associations among prenatal stress, maternal antioxidant intakes in pregnancy, and child temperament at age 30 months.Journal of developmental origins of health and disease · 2017Article
- Maternal stress modifies the effect of exposure to lead during pregnancy and 24-month old children's neurodevelopment.Environment international · 2017Article
- Maternal Exposure to Childhood Trauma Is Associated During Pregnancy With Placental-Fetal Stress Physiology.Biological psychiatry · 2016Article
- CRH as a Predictor of Preterm Birth in Minority Women.Biological research for nursing · 2016Article
- Lifetime exposure to traumatic and other stressful life events and hair cortisol in a multi-racial/ethnic sample of pregnant women.Stress (Amsterdam, Netherlands) · 2016Article
- Prenatal Stress, Prematurity, and Asthma.Obstetrical & gynecological survey · 2015Review
- Modulation of prenatal stress via docosahexaenoic acid supplementation: implications for child mental health.Nutrition reviews · 2015Review
- The Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study: design, rationale and methods.BMC pulmonary medicine · 2014Article
- Prenatal and postnatal maternal stress and wheeze in urban children: effect of maternal sensitization.American journal of respiratory and critical care medicine · 2012Article
- The association between prenatal psychosocial stress and blood pressure in the child at age 5-7 years.PloS one · 2012Article
- Maternal Lifetime Trauma Exposure, Prenatal Cortisol, and Infant Negative Affectivity.Infancy : the official journal of the International Society on Infant StudiesArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTo date, there have been conflicting reports of the association of psychosocial stressors with prenatal corticotropin-releasing hormone (CRH) levels.
methodsWe examined whether racial discrimination, community violence, interpersonal violence (IPV), negative life events, considered independently, and as a composite measure of cumulative stress, were associated with prenatal CRH levels in the Asthma Coalition on Community, Environment, and Social Stress (ACCESS) project, a multiethnic pre-birth cohort in urban Boston. Blood was collected between 20 and 37 weeks gestation (Mean=28.1, SD=4.6 weeks gestation). During pregnancy, women were administered the Conflict Tactics Scale survey to assess IPV, the Crisis in Family Systems-Revised survey to assess negative life events, the My Exposure to Violence survey to assess community violence, and the Experiences of Discrimination survey. A cumulative stress measure was derived from these instruments to characterize exposure to high levels of multiple stressors.
resultsNone of the individual stressors or cumulative stress was associated with CRH in combined analyses including Whites (n=20), Blacks (n=46), and Hispanics (n=110). In separate analyses of Blacks and Hispanics, racial discrimination, community violence, and cumulative stress were associated with CRH in Blacks, but were not associated with CRH in Hispanics.
conclusionsThough these results require replication, they suggest that the effects of stress on prenatal CRH levels may be mediated by factors that differ between racial/ethnic groups. Further studies in larger samples are warranted to clarify whether associations of chronic stressors and prenatal CRH levels differ by race/ethnicity and to better understand underlying mechanisms.
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