ReviewGender medicine2011
Evidence that the G protein-coupled membrane receptor GPR30 contributes to the cardiovascular actions of estrogen.
Review in Gender medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Ovariectomy-Induced Arterial Stiffening Differs From Vascular Aging and Is Reversed by GPER Activation.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Estrogens and the regulation of glucose metabolism.World journal of diabetes · 2021Review
- Alterations in the estrogen receptor profile of cardiovascular tissues during aging.GeroScience · 2021Article
- Factors associated with risk of major adverse cardiovascular events in patients with rheumatoid arthritis: a nationwide, population-based, case-control study.Therapeutic advances in musculoskeletal disease · 2021Article
- Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.Epigenomics · 2020Article
- Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Role of GPER in estrogen-dependent nitric oxide formation and vasodilation.The Journal of steroid biochemistry and molecular biology · 2018Article
- GPER modulators: Opportunity Nox on the heels of a class Akt.The Journal of steroid biochemistry and molecular biology · 2018Review
- The effects of oestrogens and their receptors on cardiometabolic health.Nature reviews. Endocrinology · 2017Review
- GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells.Oncotarget · 2016Article
- Activation of GPR30 inhibits cardiac fibroblast proliferation.Molecular and cellular biochemistry · 2015Article
- International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators.Pharmacological reviews · 2015Review
- G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells.Journal of neurochemistry · 2015Article
- The pathophysiology of hypertension in patients with obesity.Nature reviews. Endocrinology · 2014Review
- Estrogen biology: new insights into GPER function and clinical opportunities.Molecular and cellular endocrinology · 2014Review
- Sex differences in the pulmonary circulation: implications for pulmonary hypertension.American journal of physiology. Heart and circulatory physiology · 2014Review
- The role of tissue Renin-Angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness.Frontiers in endocrinology · 2013Review
- Reduced vasorelaxation to estradiol and G-1 in aged female and adult male rats is associated with GPR30 downregulation.American journal of physiology. Endocrinology and metabolism · 2013Article
- Sexual dimorphism: the aging kidney, involvement of nitric oxide deficiency, and angiotensin II overactivity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although female protection from cardiovascular diseases declines with the fall in circulating sex hormones experienced during menopause, clinical trials in older women fail to demonstrate beneficial effects for hormone replacement therapy. The recent discovery of GPR30, a membrane-bound estrogen receptor that is structurally and functionally unique from the steroid receptors ERα and ERβ, has unveiled additional signaling pathways by which estrogen may influence cardiovascular health. This review takes an organ-based approach to assess the expression and function of GPR30 in the cardiovascular system. We concluded that although the current literature does suggest a cardiovascular role for GPR30, additional exploration is necessary to fully elucidate the estrogenic actions mediated by this novel receptor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.