ArticleThe Journal of pediatrics2012
Placenta-imprinted gene expression association of infant neurobehavior.
Article in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 44 citations in OpenAlex.
- Placental MRI texture features in prenatal exposure to opioids and tobacco.Scientific reports · 2025Article
- Prenatal pyrethroid exposure, placental gene network modules, and neonatal neurobehavior.International journal of hygiene and environmental health · 2025Article
- Impact of intraamniotic inflammation on tryptophan metabolism in the placenta-fetal brain axis in rats.Reproduction (Cambridge, England) · 2025Article
- Evidence for neurobehavioral risk phenotypes at birth.Pediatric research · 2025Review
- Article
- Placental genomics mediates genetic associations with complex health traits and disease.Nature communications · 2022Article
- Epigenetics of the developing and aging brain: Mechanisms that regulate onset and outcomes of brain reorganization.Neuroscience and biobehavioral reviews · 2021Review
- Transcriptomics and Other Omics Approaches to Investigate Effects of Xenobiotics on the Placenta.Frontiers in cell and developmental biology · 2021Review
- The placenta-brain-axis.Journal of neuroscience research · 2021Review
- Placental Gene Expression and Offspring Temperament Trajectories: Predicting Negative Affect in Early Childhood.Journal of abnormal child psychology · 2020Article
- Effect of prematurity on genome wide methylation in the placenta.BMC medical genetics · 2019Article
- Review
- Cohort Profile: Stress in Pregnancy (SIP) Study.International journal of epidemiology · 2017Article
- Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes.Archives of gynecology and obstetrics · 2017Review
- A Role for the Placenta in Programming Maternal Mood and Childhood Behavioural Disorders.Journal of neuroendocrinology · 2016Review
- Methylation of the Glucocorticoid Receptor (NR3C1) in Placenta Is Associated with Infant Cry Acoustics.Frontiers in behavioral neuroscience · 2016Article
- DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.Genetics & epigenetics · 2016Article
- Placental DNA Methylation Related to Both Infant Toenail Mercury and Adverse Neurobehavioral Outcomes.Environmental health perspectives · 2015Article
- Environmental Influences on Genomic Imprinting.Current environmental health reports · 2015Review
- Altered placental DNA methylation patterns associated with maternal smoking: current perspectives.Advances in genomics and genetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo identify links between altered gene imprinting in the placenta and infant neurobehavioral profiles. STUDY
designQuantitative reverse-transcription polymerase chain reaction was used to examine the expression of 22 imprinted candidate genes in a series of 106 term human primary placenta tissues. The expression pattern uncovered was associated with Neonatal Intensive Care Unit Network Neurobehavioral Scales summary scores in the corresponding infants. Clustering of the expression data was used to define distinct classes of expression.
resultsSignificant associations were identified between classes of expression and the Neonatal Intensive Care Unit Network Neurobehavioral Scales quality of movement (P = .02) and handling (P = .006) scores. Multivariate regression demonstrated an independent effect of imprinted gene expression profile on these neurobehavioral scores after controlling for confounders.
conclusionThese results suggest that alterations in imprinted gene expression in the placenta are associated with infant neurodevelopmental outcomes, and suggest a role for the placenta and genomic imprinting in the placenta beyond intrauterine growth regulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.