ArticleStructure (London, England : 1993)2011
Galline Ex-FABP is an antibacterial siderocalin and a lysophosphatidic acid sensor functioning through dual ligand specificities.
Article in Structure (London, England : 1993), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Evaluating the Immunogenicity and Protective Efficacy of a Novel Vaccine Candidate AgainstVaccines · 2026Article
- Antimicrobial Proteins and Peptides in Avian Eggshell: Structural Diversity and Potential Roles in Biomineralization.Frontiers in immunology · 2022Review
- Genetic resilience in chickens against bacterial, viral and protozoal pathogens.Frontiers in veterinary science · 2022Review
- High Affinity Iron Acquisition Systems Facilitate but Are Not Essential for Colonization of Chickens byFrontiers in microbiology · 2022Article
- The Role of Ovotransferrin in Egg-White Antimicrobial Activity: A Review.Foods (Basel, Switzerland) · 2021Review
- Iron-Uptake Systems of Chicken-AssociatedMicroorganisms · 2020Review
- Scavenging Bacterial Siderophores with Engineered Lipocalin Proteins as an Alternative Antimicrobial Strategy.Chembiochem : a European journal of chemical biology · 2020Review
- The Three Lipocalins of Egg-White: Only Ex-FABP Inhibits Siderophore-Dependent Iron Sequestration byFrontiers in microbiology · 2020Article
- The anti-bacterial iron-restriction defence mechanisms of egg white; the potential role of three lipocalin-like proteins in resistance against Salmonella.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2019Article
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- Coordination Chemistry of Microbial Iron Transport.Accounts of chemical research · 2015Article
- Gene Expression Profiles of Chicken Embryo Fibroblasts in Response to Salmonella Enteritidis Infection.PloS one · 2015Article
- Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella.Veterinary research · 2014Review
- Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6.Protein & cell · 2013Article
- Siderocalins: Siderophore binding proteins evolved for primary pathogen host defense.Current opinion in chemical biology · 2013Review
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- Tryptophan rotamer distribution revealed for the α-helix in tear lipocalin by site-directed tryptophan fluorescence.The journal of physical chemistry. B · 2012Article
- Cation-π interactions in lipocalins: structural and functional implications.Biochemistry · 2012Article
- Characterization of chicken spleen transcriptome after infection with Salmonella enterica serovar Enteritidis.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Galline Ex-FABP was identified as another candidate antibacterial, catecholate siderophore binding lipocalin (siderocalin) based on structural parallels with the family archetype, mammalian Siderocalin. Binding assays show that Ex-FABP retains iron in a siderophore-dependent manner in both hypertrophic and dedifferentiated chondrocytes, where Ex-FABP expression is induced after treatment with proinflammatory agents, and specifically binds ferric complexes of enterobactin, parabactin, bacillibactin and, unexpectedly, monoglucosylated enterobactin, which does not bind to Siderocalin. Growth arrest assays functionally confirm the bacteriostatic effect of Ex-FABP in vitro under iron-limiting conditions. The 1.8 Å crystal structure of Ex-FABP explains the expanded specificity, but also surprisingly reveals an extended, multi-chambered cavity extending through the protein and encompassing two separate ligand specificities, one for bacterial siderophores (as in Siderocalin) at one end and one specifically binding copurified lysophosphatidic acid, a potent cell signaling molecule, at the other end, suggesting Ex-FABP employs dual functionalities to explain its diverse endogenous activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.