Evidence map›Paper›PMID 22153067›Full record

ArticleCell2011

A partner evokes latent differences between Hox proteins.

Aseem Z Ansari, Kimberly J Peterson-Kaufman

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Synthetic genome readers target clustered binding sites across diverse chromatin states.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Aseem Z AnsariDepartment of Biochemistry and The Genome Center, University of Wisconsin, Madison, Madison, WI 53706, USA. ansari@biochem.wisc.edu
Kimberly J Peterson-Kaufman

Funding

Midwest Progenitor Cell ConsortiumU01HL099773 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI THOMSON, JAMES ALEXANDER · 2009 to 2015
$7.8M
Targeting Leukemia causing oncogene E2a-Pbx1 with synthetic moleculesR01CA133508 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ANSARI, ASEEM Z · 2008 to 2012
$1.5M
Modular design of synthetic transcriptional regulatorsR01GM069420 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ANSARI, ASEEM Z · 2006 to 2010
$1.4M
NCI NIH HHS R01 CA133508NHLBI NIH HHS U01 HL099773NIGMS NIH HHS R01 GM069420
6 · The paper itself

Abstract

Hox transcription factors bind highly related DNA sequences in vitro, yet they regulate different genes and play distinct roles in anterior-posterior patterning in animals. Slattery et al. report that a common cofactor, Exd, accentuates latent sequence specificities of all eight Hox proteins and directs binding to relevant sites across the genome.

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.