Evidence map›Paper›PMID 22152946›Full record

ReviewCurrent opinion in cell biology2012

Putting structure into context: fitting of atomic models into electron microscopic and electron tomographic reconstructions.

Niels Volkmann

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Efficient Extraction of Macromolecular Complexes from Electron Tomograms Based on Reduced Representation Templates.Computer analysis of images and patterns : proceedings of the ... International Conference on Automatic Image Processing. International Conference on Automatic Image Processing · 2015
    Article
  4. Article
  5. Article
  6. Assembly of macromolecular complexes by satisfaction of spatial restraints from electron microscopy images.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
  7. Electron crystallography--the waking beauty of structural biology.Current opinion in structural biology · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Niels VolkmannSanford-Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA. niels@sanfordburnham.org

Funding

STRUCTUREU54GM064346 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI IMPERIALI, BARBARA · 2001 to 2010
$74.9M
Structure and function of Arp 2/3 complex--Subproject 4P01GM066311 · NIGMS · YALE UNIVERSITY · PI LI, RONG · 2003 to 2013
$16.8M
Ultrastructural Basis of Mechanotransduction in Matrix AdhesionsP01GM098412 · NIGMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI GROISMAN, ALEX · 2011 to 2015
$8.0M
NIGMS NIH HHS GM066311NIGMS NIH HHS GM098412NIGMS NIH HHS P01 GM066311NIGMS NIH HHS P01 GM098412NIGMS NIH HHS U54 GM064346
6 · The paper itself

Abstract

A complete understanding of complex dynamic cellular processes such as cell migration or cell adhesion requires the integration of atomic level structural information into the larger cellular context. While direct atomic-level information at the cellular level remains inaccessible, electron microscopy, electron tomography and their associated computational image processing approaches have now matured to a point where sub-cellular structures can be imaged in three dimensions at the nanometer scale. Atomic-resolution information obtained by other means can be combined with this data to obtain three-dimensional models of large macromolecular assemblies in their cellular context. This article summarizes some recent advances in this field.

Indexed as

Electron Microscope TomographyMicroscopy, ElectronAnimalsBacteriaEukaryotic CellsHumansImage Processing, Computer-Assisted

Identifiers

PMID22152946
PMCPMC3294126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.