ArticleFunctional neurology
Effect of prior medical treatments on ischemic stroke severity and outcome.
Article in Functional neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Pre-Stroke Statin Use Is Associated with Mild Neurological Deficits at the Onset of Acute Ischemic Stroke.Journal of cardiovascular development and disease · 2022Article
- Total Cerebral Small Vessel Disease Score and Cerebral Bleeding Risk in Patients With Acute Stroke Treated With Intravenous Thrombolysis.Frontiers in aging neuroscience · 2022Article
- Do statins reduce the mortality rate in stroke patients treated with systemic thrombolysis in a 5-year.Neural regeneration research · 2021Article
- Relationship between pre-stroke cardiovascular medication use and stroke severity.European journal of clinical pharmacology · 2016Article
- Statins in Acute Ischemic Stroke: A Systematic Review.Journal of stroke · 2015Review
- Effect of pre-stroke statin use on stroke severity and early functional recovery: a retrospective cohort study.BMC neurology · 2015Article
- Statin therapy does not affect the radiographic and clinical profile of patients with TIA and minor stroke.AJNR. American journal of neuroradiology · 2015Article
- Association between insufficient medication of antihypertensives and the severity of acute ischemic stroke.Clinical hypertension · 2015Article
- Clinical factors associated with statins prescription in acute ischemic stroke patients: findings from the Lombardia Stroke Registry.BMC neurology · 2014Article
- Cardiac abnormalities after aneurysmal subarachnoid hemorrhage: effects of β-blockers and angiotensin-converting enzyme inhibitors.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2014Article
- The THRombolysis and STatins (THRaST) study.Neurology · 2013Article
- Effect of previous statin therapy on severity and outcome in ischemic stroke patients: a population-based study.Journal of neurology · 2013Article
- Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antiplatelets, antihypertensives, and statins might reduce the severity of the event or improve outcome in patients who, despite prior medical treatment, have a stroke. We evaluated, in patients who had an ischemic stroke, the effect, on stroke severity and outcome, of prior treatment with antiplatelets, antihypertensives, and statins, used either alone or in a three-drug combination. Stroke in Italy and Related Impact on Outcome (SIRIO) was a prospective, nationwide, multicenter, hospital-based, observational study that included patients aged.18 years with acute ischemic stroke. We studied 2,529 acute ischemic stroke patients from the SIRIO population: 887 were antiplatelet users, 1,497 antihypertensive users, 231 statin users, and 138 three-drug combination users prior to the index event. The adjusted logistic regression analysis showed an association between prior treatment with statins and good functional outcome at discharge, while prior treatment with antiplatelets, antihypertensives or the three-drug combination did not influence severity or outcome. The absolute probability of a good functional outcome was 46.3% (95% CI: 40.3%-53.2%) in statin users and 36.7% (95% CI: 34.7%-38.7%) in non-users of statins; the absolute risk difference was 9.6% (95% CI: 2.9%-16.4%; p=0.004). Prior treatment with antiplatelets, antihypertensives, or the three-drug combination did not influence stroke severity or outcome, while prior treatment with statins did not influence stroke severity but was associated with a better functional outcome.
Indexed as
Identifiers
22152434PMC3814556W1598936855What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.