ArticleHealth and quality of life outcomes2011
The relative impact of vision impairment and cardiovascular disease on quality of life: the example of pseudoxanthoma elasticum.
Article in Health and quality of life outcomes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterization of Patients With Pseudoxanthoma Elasticum
Employment Retention Issues for Patient With Pseudoxanthoma Elasticum
Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Aflibercept for choroidal neovascularizations secondary to pseudoxanthoma elasticum: a prospective study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Trial
- Article
- Quality of life impact of eye diseases: a Save Sight Registries study.Clinical & experimental ophthalmology · 2022Article
- The complexity of visual dysfunction in patients with pseudoxanthoma elasticum.Eye (London, England) · 2022Article
- Minocycline Counteracts Ectopic Calcification in a Murine Model of Pseudoxanthoma Elasticum: A Proof-of-Concept Study.International journal of molecular sciences · 2022Article
- Review
- Should We Perform Early Cataract Surgery? A Patient Reported Outcome Study.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Statement of the BVA, the DOG, and the RG on treatment of choroidal neovascularization in diseases other than neovascular age-related macular degeneration : Dated Ocotber 2017.Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Article
- [Statement from the BVA, the DOG, and the RG on treatment of choroidal neovascularization in diseases other than neovascular age-related macular degeneration : October 2017].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2018Article
- Pseudoxanthoma elasticum.Orphanet journal of rare diseases · 2017Review
- Reducing respondent burden: validation of the Brief Impact of Vision Impairment questionnaire.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017Article
- Assessment of the psychometric properties of the Chinese Impact of Vision Impairment questionnaire in a population-based study: findings from the Singapore Chinese Eye Study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- An update on the ocular phenotype in patients with pseudoxanthoma elasticum.Frontiers in genetics · 2013Article
- A case of pseudoxantoma elasticum.Journal of ocular biology, diseases, and informatics · 2012Article
- Case report: Grönblad-Strandberg syndrome.Romanian journal of ophthalmologyArticle
- Epidemiology of Angioid Streaks and Pseudoxanthoma Elasticum (2011-2020): A Nationwide Population-based Cohort Study.Ophthalmology scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the impact of pseudoxanthoma elasticum (PXE), a rare hereditary disease of concurrent vision impairment (VI) and cardiovascular complications (CVCs), on vision-related (VRQoL) and health-related quality of life (HRQoL).
methodsVRQoL and HRQoL were assessed using the Impact of Vision Impairment (IVI) questionnaire and the Short Form Health Survey (SF-36) in 107 PXE patients. Patients were stratified into four groups: A = no VI or CVC; B = CVCs only; C = VI only; and D = both VI and CVCs.
resultsFollowing Rasch analysis, the IVI was found to function as a vision-specific functioning and emotional well-being subscale, and the SF-36 as a health-related physical functioning and mental health subscale. The presence of VI and CVC were significant predictors of vision-specific functioning and emotional well-being (p < 0.001), with a clinically meaningful decrement in vision-specific functioning in patients with VI. No associations were found for the SF-36 Physical Functioning and Mental Health scores between any groups.
conclusionsVision impaired patients with PXE report significantly poorer vision-specific functioning than PXE patients without VI. In contrast, the relative impact of PXE on reported general HRQoL was much less. Our results suggest that vision impairment has the larger impact on QoL in this sample.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.