ArticleAging cell2012
CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength.
Article in Aging cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons.Physiological genomics · 2016Pooled it
- Ablation of Vitamin D Signaling in Cardiomyocytes Leads to Functional Impairment and Stimulation of Pro-Inflammatory and Pro-Fibrotic Gene Regulatory Networks in a Left Ventricular Hypertrophy Model in Mice.International journal of molecular sciences · 2024Article
- Profiling of open chromatin in developing pig (Sus scrofa) muscle to identify regulatory regions.G3 (Bethesda, Md.) · 2022Article
- Comparative Proteomic Analysis of Polarized Human THP-1 and Mouse RAW264.7 Macrophages.Frontiers in immunology · 2021Article
- Skewed macrophage polarization in aging skeletal muscle.Aging cell · 2019Article
- The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood.Biogerontology · 2019Article
- Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength.Biogerontology · 2019Article
- Metabolic and molecular framework for the enhancement of endurance by intermittent food deprivation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Altered Lipid Metabolism Impairs Skeletal Muscle Force in Young Rats Submitted to a Short-Term High-Fat Diet.Frontiers in physiology · 2018Article
- Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans.Aging cell · 2016Article
- GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.Aging cell · 2016Article
- CCAAT-enhancer binding protein (C/EBP) β regulates insulin-like growth factor (IGF) 1 expression in porcine liver during prenatal and postnatal development.Molecular and cellular biochemistry · 2015Article
- C/EBPβ LIP induces a tumor menagerie making it an oncogene.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise.The journal of physiological sciences : JPS · 2015Article
- Cellular reprogramming for understanding and treating human disease.Frontiers in cell and developmental biology · 2014Review
- Changes in splicing factor expression are associated with advancing age in man.Mechanisms of ageing and development · 2013Article
- Molecular and functional analyses of the fast skeletal myosin light chain2 gene of the Korean oily bitterling, Acheilognathus koreensis.International journal of molecular sciences · 2013Article
- Genome-wide methylated DNA immunoprecipitation analysis of patients with polycystic ovary syndrome.PloS one · 2013Article
- Genomics and successful aging: grounds for renewed optimism?The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
Declining muscle strength is a core feature of aging. Several mechanisms have been postulated, including CCAAT/enhancer-binding protein-beta (C/EBP-β)-triggered macrophage-mediated muscle fiber regeneration after micro-injury, evidenced in a mouse model. We aimed to identify in vivo circulating leukocyte gene expression changes associated with muscle strength in the human adult population. We undertook a genome-wide expression microarray screen, using peripheral blood RNA samples from InCHIANTI study participants (aged 30 and 104). Logged expression intensities were regressed with muscle strength using models adjusted for multiple confounders. Key results were validated by real-time PCR. The Short Physical Performance Battery (SPPB) score tested walk speed, chair stand, and balance. CEBPB expression levels were associated with muscle strength (β coefficient = 0.20560, P = 1.03*10(-6), false discovery rate q = 0.014). The estimated handgrip strength in 70-year-old men in the lowest CEBPB expression tertile was 35.2 kg compared with 41.2 kg in the top tertile. CEBPB expression was also associated with hip, knee, ankle, and shoulder strength and the SPPB score (P = 0.018). Near-study-wide associations were also noted for TGF-β3 (P = 3.4*10(-5) , q = 0.12) and CEBPD expression (P = 9.7*10(-5) , q = 0.18) but not for CEBPA expression. We report here a novel finding that raised CEBPB expression in circulating leukocyte-derived RNA samples in vivo is associated with greater muscle strength and better physical performance in humans. This association may be consistent with mouse model evidence of CEBPB-triggered muscle repair: if this mechanism is confirmed, it may provide a target for intervention to protect and enhance aging muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.