Evidence map›Paper›PMID 22151581›Full record

ReviewNeuropathology : official journal of the Japanese Society of Neuropathology2012

Isoform diversity and its importance for axon regeneration.

Jessica K Lerch, John L Bixby, Vance P Lemmon

Abstract readReview
In one paragraph

Review in Neuropathology : official journal of the Japanese Society of Neuropathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jessica K LerchThe Miami Project to Cure Paralysis, The University of Miami, Miami, FL, USA.
John L Bixby
Vance P Lemmon

Funding

Novel Gene Targets for CNS Axonal RegenerationR01HD057632 · NICHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BIXBY, JOHN L, LEMMON, VANCE P · 2007 to 2018
$4.7M
Novel Compounds That Overcome Glial Inhibition of Axonal RegenerationR01NS059866 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BIXBY, JOHN L · 2009 to 2013
$1.7M
NICHD NIH HHS HD057632NICHD NIH HHS R01 HD057632NINDS NIH HHS NS059866NINDS NIH HHS R01 NS059866
6 · The paper itself

Abstract

Axon regeneration is a fundamental problem facing neuroscientists and clinicians. Failure of axon regeneration is caused by both extrinsic and intrinsic mechanisms. New techniques to examine gene expression such as Next Generation Sequencing of the Transcriptome (RNA-Seq) drastically increase our knowledge of both gene expression complexity (RNA isoforms) and gene expression regulation. By utilizing RNA-Seq, gene expression can now be defined at the level of isoforms, an essential step for understanding the mechanisms governing cell identity, growth and ultimately cellular responses to injury and disease.

Indexed as

AnimalsAxonsHumansNerve RegenerationProtein IsoformsProtein Isoforms

Identifiers

PMID22151581
PMCPMC3309121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.