ArticleThe European journal of neuroscience2012
Mixed electrical-chemical transmission between hippocampal mossy fibers and pyramidal cells.
Article in The European journal of neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Association of connexin36 with adherens junctions at mixed synapses and distinguishing electrophysiological features of those at mossy fiber terminals in rat ventral hippocampus.International journal of physiology, pathophysiology and pharmacology · 2024Article
- Neuronal Glutamatergic Network Electrically Wired with Silent But Activatable Gap Junctions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Connexins-Based Hemichannels/Channels and Their Relationship with Inflammation, Seizures and Epilepsy.International journal of molecular sciences · 2019Review
- On the occurrence and enigmatic functions of mixed (chemical plus electrical) synapses in the mammalian CNS.Neuroscience letters · 2019Review
- Early Appearance and Spread of Fast Ripples in the Hippocampus in a Model of Cortical Traumatic Brain Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Electrical synapses in mammalian CNS: Past eras, present focus and future directions.Biochimica et biophysica acta. Biomembranes · 2018Review
- Antidromic-rectifying gap junctions amplify chemical transmission at functionally mixed electrical-chemical synapses.Nature communications · 2017Article
- Three-dimensional synaptic analyses of mitral cell and external tufted cell dendrites in rat olfactory bulb glomeruli.The Journal of comparative neurology · 2017Article
- Does Epileptiform Activity Represent a Failure of Neuromodulation to Control Central Pattern Generator-Like Neocortical Behavior?Frontiers in neural circuits · 2017Article
- Article
- Dopamine/Tyrosine Hydroxylase Neurons of the Hypothalamic Arcuate Nucleus Release GABA, Communicate with Dopaminergic and Other Arcuate Neurons, and Respond to Dynorphin, Met-Enkephalin, and Oxytocin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Modelling the Effects of Electrical Coupling between Unmyelinated Axons of Brainstem Neurons Controlling Rhythmic Activity.PLoS computational biology · 2015Article
- Electrical synapses and their functional interactions with chemical synapses.Nature reviews. Neuroscience · 2014Review
- Article
- Connexin36 in gap junctions forming electrical synapses between motoneurons in sexually dimorphic motor nuclei in spinal cord of rat and mouse.The European journal of neuroscience · 2014Article
- Roles of gap junctions, connexins, and pannexins in epilepsy.Frontiers in physiology · 2014Review
- Mixed neurotransmission in the hippocampal mossy fibers.Frontiers in cellular neuroscience · 2013Review
- Article
- Axonal properties determine somatic firing in a model of in vitro CA1 hippocampal sharp wave/ripples and persistent gamma oscillations.The European journal of neuroscience · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Morphological and electrophysiological studies have shown that granule cell axons, the mossy fibers (MFs), establish gap junctions and therefore electrical communication among them. That granule cells express gap junctional proteins in their axons suggests the possibility that their terminals also express them. If this were to be the case, mixed electrical-chemical communication could be supported, as MF terminals normally use glutamate for fast communication with their target cells. Here we present electrophysiological studies in the rat and modeling studies consistent with this hypothesis. We show that MF activation produced fast spikelets followed by excitatory postsynaptic potentials in pyramidal cells (PCs), which, unlike the spikelets, underwent frequency potentiation and were strongly depressed by activation of metabotropic glutamate receptors, as expected from transmission of MF origin. The spikelets, which persisted during blockade of chemical transmission, were potentiated by dopamine and suppressed by the gap junction blocker carbenoxolone. The various waveforms evoked by MF stimulation were replicated in a multi-compartment model of a PC by brief current-pulse injections into the proximal apical dendritic compartment, where MFs are known to contact PCs. Mixed electrical and glutamatergic communication between granule cells and some PCs in CA3 may ensure the activation of sets of PCs, bypassing the strong action of concurrent feed-forward inhibition that granule cells activate. Importantly, MF-to-PC electrical coupling may allow bidirectional, possibly graded, communication that can be faster than chemical synapses and subject to different forms of modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.