ArticleVeterinary research2011
Stress induced Salmonella Typhimurium recrudescence in pigs coincides with cortisol induced increased intracellular proliferation in macrophages.
Article in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 78 citations in OpenAlex.
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- Fecal microbial composition associated with testosterone in the development of Meishan male pigs.Frontiers in microbiology · 2023Article
- Transmission of antimicrobial resistance (AMR) during animal transport.EFSA journal. European Food Safety Authority · 2022Article
- High Dietary Intake of Rye Affects Porcine Gut Microbiota in aPlants (Basel, Switzerland) · 2022Article
- Epidemiological Study onMicroorganisms · 2022Article
- Prevalence of gross lesions and handling practices in pigs and their association with pork quality, Kiambu, Kenya.PloS one · 2022Article
- Understanding the effects of intramuscular injection and feed withdrawal on Salmonella Typhimurium shedding and gut microbiota in pullets.Journal of animal science and biotechnology · 2021Article
- Thymol and Carvacrol Downregulate the Expression ofMicroorganisms · 2020Article
- Research Note: Evaluation of a heat stress model to induce gastrointestinal leakage in broiler chickens.Poultry science · 2020Article
- Interkingdom Cross-Talk in Times of Stress:Frontiers in immunology · 2020Article
- Adrenal Steroids Modulate Fibroblast-Like Synoviocytes Response DuringFrontiers in endocrinology · 2019Article
- Organic Acids Modulate Systemic Metabolic Perturbation Caused byFrontiers in physiology · 2019Article
- Article
- Campylobacteriosis, Salmonellosis, Yersiniosis, and Listeriosis as Zoonotic Foodborne Diseases: A Review.International journal of environmental research and public health · 2018Review
- Time course ofCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2018Article
- Inhibition of Osteoblast Function byFrontiers in immunology · 2018Article
- Salmonella Co-opts Host Cell Chaperone-mediated Autophagy for Intracellular Growth.The Journal of biological chemistry · 2017Article
- CRH Affects the Phenotypic Expression of Sepsis-Associated Virulence Factors byFrontiers in cellular and infection microbiology · 2017Article
- Optimizing Fluorescein Isothiocyanate Dextran Measurement As a Biomarker in a 24-h Feed Restriction Model to Induce Gut Permeability in Broiler Chickens.Frontiers in veterinary science · 2017Article
- Host Stress Drives Salmonella Recrudescence.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella Typhimurium infections in pigs often result in the development of carriers that intermittently excrete Salmonella in very low numbers. During periods of stress, for example transport to the slaughterhouse, recrudescence of Salmonella may occur, but the mechanism of this stress related recrudescence is poorly understood. Therefore, the aim of the present study was to determine the role of the stress hormone cortisol in Salmonella recrudescence by pigs. We showed that a 24 h feed withdrawal increases the intestinal Salmonella Typhimurium load in pigs, which is correlated with increased serum cortisol levels. A second in vivo trial demonstrated that stress related recrudescence of Salmonella Typhimurium in pigs can be induced by intramuscular injection of dexamethasone. Furthermore, we found that cortisol, but not epinephrine, norepinephrine and dopamine, promotes intracellular proliferation of Salmonella Typhimurium in primary porcine alveolar macrophages, but not in intestinal epithelial cells and a transformed cell line of porcine alveolar macrophages. A microarray based transcriptomic analysis revealed that cortisol did not directly affect the growth or the gene expression or Salmonella Typhimurium in a rich medium, which implies that the enhanced intracellular proliferation of the bacterium is probably caused by an indirect effect through the cell. These results highlight the role of cortisol in the recrudescence of Salmonella Typhimurium by pigs and they provide new evidence for the role of microbial endocrinology in host-pathogen interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.