ArticleInternational journal of andrology2012
Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta.
Article in International journal of andrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis.Human reproduction update · 2016Pooled it
- Effect of plastic composition in the combustion material on the Persistent Organic Pollutant content in smoked chicken meat.PloS one · 2026Article
- Effect of Plastic Composition in the Combustion Material on the Persistent Organic Pollutant Content in Smoked Dried Shiitake Mushroom.Journal of analytical methods in chemistry · 2026Article
- The epidemiology of cryptorchidism and potential risk factors, including endocrine disrupting chemicals.Frontiers in endocrinology · 2024Review
- Endocrine Disrupting Chemicals' Effects in Children: What We Know and What We Need to Learn?International journal of molecular sciences · 2022Review
- Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men.Frontiers in endocrinology · 2021Review
- Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models.Advances in pharmacology (San Diego, Calif.) · 2021Article
- Review
- The Impact of Bisphenol A on Fertility, Reproductive System, and Development: A Review of the Literature.International journal of endocrinology · 2019Review
- Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food.EFSA journal. European Food Safety Authority · 2018Article
- Risk factors for cryptorchidism.Nature reviews. Urology · 2017Review
- Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility.Physiological reviews · 2016Review
- EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.Endocrine reviews · 2015Review
- Cumulative Chemical Exposures During Pregnancy and Early Development.Current environmental health reports · 2015Review
- Association between levels of persistent organic pollutants in adipose tissue and cryptorchidism in early childhood: a case-control study.Environmental health : a global access science source · 2015Article
- Blood levels of polychlorinated biphenlys and organochlorinated pesticides in women from Istanbul, Turkey.Environmental monitoring and assessment · 2015Article
- Serum Bisphenol A Level in Boys with Cryptorchidism: A Step to Male Infertility?International journal of endocrinology · 2015Article
- In utero exposure to persistent organochlorine pollutants and reproductive health in the human male.Reproduction (Cambridge, England) · 2014Article
- Possible fetal determinants of male infertility.Nature reviews. Endocrinology · 2014Review
- Association of placenta organotin concentrations with growth and ponderal index in 110 newborn boys from Finland during the first 18 months of life: a cohort study.Environmental health : a global access science source · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In animal studies, exposure to dioxins has been associated with disrupted development of the male reproductive system, including testicular maldescent. Some polychlorinated biphenyls (PCBs) have also dioxin-like effects. In addition, one previous case-control study has reported an association between congenital cryptorchidism and colostrum PCB levels. We performed a case-control study to evaluate whether congenital cryptorchidism in boys was associated with increased levels of dioxins or PCBs in placenta reflecting foetal exposure. In addition, associations between placenta levels of these chemicals and reproductive hormone levels in boys at 3 months were studied. Placentas were collected in a Danish-Finnish joint prospective cohort study on cryptorchidism (1997-2001). The boys were examined for cryptorchidism at birth and at 3 months. Altogether, 280 placentas [112 Finnish (56 cases, 56 controls) and 168 Danish (39 cases, 129 controls)] were analysed for 17 toxic polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and 37 PCBs (including 12 dioxin-like PCBs). Infant serum samples taken at 3 months were analysed for reproductive hormones. No significant differences between cases and controls were observed in either country in dioxin WHO-TEq levels (median 9.78 vs. 8.47 pg/g fat, respectively, in Finland, and 11.75 vs. 10.88 pg/g fat in Denmark) or PCB WHO-TEq levels (median 2.12 vs. 2.15 pg/g fat in Finland, 2.34 vs. 2.10 pg/g fat in Denmark) or total-TEq levels (median 11.66 vs. 10.58 pg/g fat in Finland, 13.94 vs. 13.00 pg/g fat in Denmark). Placenta WHO-TEq levels of dioxins were not associated with infant reproductive hormone levels at 3 months. In Finland, PCB WHO-TEq levels in placenta associated positively with infant LH levels. WHO-TEq levels of dioxins and PCBs and total-TEq levels were higher in Danish than Finnish samples. In conclusion, no association between placenta levels of dioxins or PCBs and congenital cryptorchidism was found. Significant country differences in chemical levels were observed.
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Registered trials
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