ArticleExpert review of vaccines2012
A novel genetically engineered Mycobacterium smegmatis-based vaccine promotes anti-TB immunity.
Article in Expert review of vaccines, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Enhanced priming of adaptive immunity by Mycobacterium smegmatis mutants with high-level protein secretion.Clinical and vaccine immunology : CVI · 2012Article
Corrections and comments
- Comment on
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary TB remains a global health threat. Prophylactic immunization with Mycobacterium bovis BCG is the only key strategy to control TB. Ineffectiveness of BCG immunization in TB-endemic areas and BCG-related safety issues in HIV-positive infants have prompted the development of new TB vaccines. As enhanced understanding of the immune evasion mechanism of Mycobacterium tuberculosis will help develop new vaccines, Sweeney et al. studied the role of the esx-3 locus in mycobacterial pathogenesis. They have identified a previously unappreciated function of the esx-3 locus in innate immune evasion. They further discovered that Mycobacterium smegmatis with the esx-3 genes deleted could function as a novel vaccine vector with an enhanced innate immune-activating property. This vector, when engineered to express M. tuberculosis esx-3, was found to be a potent TB vaccine capable of a level of protection superior to that of BCG when administered via the intravenous route.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.