Evidence map›Paper›PMID 22149279›Full record

ArticleHybridoma (2005)2011

A mouse monoclonal antibody against the γ2 subunit of GABAA receptors.

Suchitra Joshi, Chengsan Sun, Jaideep Kapur

Abstract read
In one paragraph

Article in Hybridoma (2005), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Homeostatic strengthening of inhibitory synapses is mediated by the accumulation of GABA(A) receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Suchitra JoshiDepartment of Neurology, University of Virginia, Health Sciences Center, Charlottesville, 22908, USA.
Chengsan Sun
Jaideep Kapur

Funding

TREATMENT OF STATUS EPILEPTICUSR01NS040337 · NINDS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KAPUR, JAIDEEP · 2000 to 2021
$5.0M
Neurosteroid Regulation of SeizuresR01NS044370 · NINDS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KAPUR, JAIDEEP · 2003 to 2017
$4.1M
NINDS NIH HHS R01 NS 040337NINDS NIH HHS R01 NS044370
6 · The paper itself

Abstract

A mouse monoclonal antibody directed against the N terminal extracellular epitope of rat γ amino butyric acid (GABA) type-A (GABA(A)R) receptor γ2 subunit was generated. This antibody identified a protein of approximately 42 kDa in Western blot assays using rat and mouse hippocampal proteins. The antibody also detected the expression of γ2 subunit by immunohistochemistry and could immunoprecipitate the γ2 subunit.

Indexed as

Antibody SpecificityAmino Acid SequenceAnimalsAntibodies, Monoclonal, Murine-DerivedAntigen-Antibody ReactionsBlotting, WesternHEK293 CellsHippocampusHumansHybridomasImmune SeraImmunizationImmunohistochemistryImmunoprecipitationMaleMiceAntibodies, Monoclonal, Murine-DerivedGabrg2 protein, ratImmune SeraReceptors, GABA-A

Identifiers

PMID22149279
PMCPMC3278817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.