ArticleJournal of women's health (2002)2012
Gender differences in colorectal cancer incidence in the United States, 1975-2006.
Article in Journal of women's health (2002), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Ethnic Enclave Residence and Breast, Cervical, and Colorectal Cancer Incidence among Asian American Adults, 2006 to 2017.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Epidemiology of colonic adenoma and cancer.Clinical endoscopy · 2026Review
- Estrogen receptors and the NRF2 pathway: bridging hormonal regulation and stress response in the gut.Frontiers in endocrinology · 2026Review
- Sex and gender-oriented colorectal cancer screening: a consensus study from the AIOM- GISEG working group.Frontiers in oncology · 2026Article
- Y-chromosome alteration and its impact on cancer progression and metastasis.Cellular & molecular biology letters · 2025Review
- A Real-World Pharmacovigilance Study of Fruquintinib Based on the FDA Adverse Event Reporting System (FAERS) Database.Cancer medicine · 2025Article
- Integrating the secretome and interactome to identify novel biomarkers and therapeutic targets in colorectal cancer.Cell communication and signaling : CCS · 2025Article
- Sex Differences in Colorectal Cancer: Epidemiology, Risk Factors, and Clinical Outcomes.Journal of clinical medicine · 2025Review
- Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk?Cancer & metabolism · 2025Article
- Melanoma and Colorectal Cancer as Second Primary Cancers: A Scoping Review of Their Association and the Underlying Biological, Lifestyle, and Genetic Factors.Journal of gastrointestinal cancer · 2025Article
- An Investigation into the Effects of Frailty and Sarcopenia on Postoperative Anesthesia Recovery and Complications Among Geriatric Patients Undergoing Colorectal Malignancy Surgery.Medicina (Kaunas, Lithuania) · 2025Article
- Unraveling Early Onset Disparities and Determinants: An Analysis of Colorectal Cancer Outcomes and Trends in Texas.Cureus · 2025Article
- Pathologic Features of Rectal Adenocarcinoma after Preoperative Neoadjuvant Chemoradiation Therapy and the Prognostic Factors for Local Recurrence: A Retrospective Study at Maharaj Nakorn Chiang Mai Hospital.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Exploring Cancer Incidence Trends by Age and Sex Among 14.14 Million Individuals in China From 2007 to 2021: Population-Based Study.JMIR public health and surveillance · 2024Article
- The Influence of Sex and/or Gender on the Occurrence of Colorectal Cancer in the General Population in Developed Countries: A Scoping Review.International journal of public health · 2024Article
- Mortality-to-incidence ratio of early-onset colorectal cancer in high-income Asian and Middle Eastern countries: A systemic analysis of the Global Burden of Diseases Study 2019.Cancer medicine · 2023Article
- Chronic kidney diseases and the risk of colorectal cancer: A systematic review and meta-analysis.Arab journal of urology · 2023Review
- Colon Cancer: From Epidemiology to Prevention.Metabolites · 2022Review
- Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance.Clinical epigenetics · 2021Review
- The gut microbiota is a major regulator of androgen metabolism in intestinal contents.American journal of physiology. Endocrinology and metabolism · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGender differences have been documented among patients diagnosed with colorectal cancer (CRC). It is still not clear, however, how these differences have changed over the past 30 years and if these differences vary by geographic areas. We examined trends in CRC incidence between 1975 and 2006.
methodsThe study population consisted of 373,956 patients ≥40 years diagnosed with malignant CRC between 1975 and 2006 who resided in one of the nine Surveillance, Epidemiology and End Results (SEER) regions of the United States. Age-adjusted incidence rates over time were reported by gender, race, CRC subsite, stage, and SEER region.
resultsOverall, CRC was diagnosed in roughly equal numbers of men (187,973) and women (185,983). Men had significantly higher age-adjusted CRC incidence rates across all categories of age, race, tumor subsite, stage, and SEER region. Gender differences in CRC age-adjusted incidence rates widened slightly from 1975 to 1988, reached a peak in 1985-1988, and have narrowed over time since 1990. The largest gap and decline in CRC incidence rates between men and women were observed among those ≥80 years (p<0.001), followed by those 70-79 and then 60-69 years. Gender differences in CRC incidence rates for the 40-49 and 50-59 age categories were small and increased only slightly over time (p=0.003).
conclusionsHigher CRC age-adjusted incidence among men than among women has persisted over the past 30 years. Although gender differences narrowed in the population ≥60 years, especially from 1990 to 2006, gender gaps, albeit small ones, in those younger than 60 increased over time. Future studies may need to examine the factors associated with these differences and explore ways to narrow the gender gap.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.