ArticleJournal of neurogastroenterology and motility2011
Alterations of colonic contractility in long-term diabetic rat model.
Article in Journal of neurogastroenterology and motility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Blunting of Colon Contractions in Diabetics with Gastroparesis Quantified by Wireless Motility Capsule Methods.PloS one · 2015Trial
- Effects of GLP-1 and GIP on cholinergic-induced contractility in isolated jejunal muscle from obese patients with and without type 2 diabetes mellitus.Frontiers in physiology · 2025Article
- Histomorphometry Changes and Decreased Reactivity to Angiotensin II in the Ileum and Colon of Streptozotocin-Induced Diabetic Rats.International journal of molecular sciences · 2022Article
- The Altered Signaling on EFS-Induced Colon Contractility in Diabetic Rats.Biomolecules & therapeutics · 2020Article
- The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat.Biomolecules & therapeutics · 2019Article
- The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Diabetes-induced mechanophysiological changes in the small intestine and colon.World journal of diabetes · 2017Review
- Abdominal Manual Therapy Repairs Interstitial Cells of Cajal and Increases Colonic c-Kit Expression When Treating Bowel Dysfunction after Spinal Cord Injury.BioMed research international · 2017Article
- Change in the Interstitial Cells of Cajal and nNOS Positive Neuronal Cells with Aging in the Stomach of F344 Rats.PloS one · 2017Article
- Characterization of smooth muscle, enteric nerve, interstitial cells of Cajal, and fibroblast-like cells in the gastric musculature of patients with diabetes mellitus.World journal of gastroenterology · 2016Article
- Diabetes-related dysfunction of the small intestine and the colon: focus on motility.Current diabetes reports · 2015Review
- Visceral Hypersensitivity and Altered Colonic Motility in Type 2 Diabetic Rat.Journal of neurogastroenterology and motility · 2015Article
- Interleukin-6 (IL-6) mediated the increased contraction of distal colon in streptozotocin-induced diabetes in rats via IL-6 receptor pathway.International journal of clinical and experimental pathology · 2015Article
- Is this the era of interstitial cells of cajal transplantation?Journal of neurogastroenterology and motility · 2014Article
- Changes of phasic and tonic smooth muscle function of jejunum in type 2 diabetic Goto-Kakizaki rats.World journal of diabetes · 2013Article
- Impact of myenteric plexus alterations on diabetes related gastrointestinal dysmotility.Journal of neurogastroenterology and motility · 2013Article
- The important roles of interstitial cells of cajal and cholinergic receptors on diabetes related dysfunction of colon.Journal of neurogastroenterology and motility · 2011Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsDysfunction of the gastrointestinal tract occurs in about 76% of patients who are diabetic for more than 10 years. Although diabetes-related dysfunctions of the stomach such as gastroparesis have been extensively studied over the recent years, studies about the mechanism underlying colonic symptoms in long-term diabetes models are rare. Therefore, the goal of our study was to clarify the nature of colonic dysfunction in a long-term diabetic rat model.
methodsThe characteristics of colonic smooth muscle were investigated in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. These results were compared to those obtained from Long-Evans Tokushima Otsuka (LETO) control rats.
resultsSpontaneous contractility of the proximal colon was significantly decreased in the diabetic rats compared to the controls, while the spontaneous contractility of the distal colon was not. The number of interstitial cells of Cajal networks in the proximal colon was greatly decreased in diabetic rats compared to the controls. Contractility of the proximal colon in response to carbachol, an acetylcholine receptor agonist, was significantly weaker in the diabetic rats. In addition, the degree of relaxation in response to nitric oxide in the proximal colon of diabetic rats also appeared to be attenuated.
conclusionsThe results from our study suggest that the decrease of interstitial cells of Cajal network, cholinergic receptors, and neuronal nitric oxide synthase in the proximal colon plays important roles in diabetes-related dysfunction of colon.
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