ReviewChest2011
Clostridium difficile in the ICU: the struggle continues.
Review in Chest, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07221370 (Enteral Vancomycin as Primary Prophylaxis Against Clostridioides Difficile Infection in Critically Ill Patients), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enteral Vancomycin as Primary Prophylaxis Against Clostridioides Difficile Infection in Critically Ill Patients
Who cites it
21 citing papers in PubMed, 73 citations in OpenAlex.
- Impact of targeted interventions on healthcare-acquired infection prevention and control of Clostridium difficile infections.Antimicrobial resistance and infection control · 2025Article
- Risk Factors and Outcomes of Clostridioides difficile Infection in Respiratory Intensive Care Unit Patients.The clinical respiratory journal · 2025Article
- Importance of Ultraviolet-C (UV-C) Emitter Configuration for Clostridioides difficile Attenuation.Cureus · 2024Article
- Article
- Risk factors and intestinal microbiota: Clostridioides difficile infection in patients receiving enteral nutrition at Intensive Care Units.Critical care (London, England) · 2020Article
- Risk factors for Clostridioides difficile infection and colonization among patients admitted to an intensive care unit in Shanghai, China.BMC infectious diseases · 2019Article
- Clostridium difficile toxin B induces autophagic cell death in colonocytes.Journal of cellular and molecular medicine · 2018Article
- Epidemiology ofThe open microbiology journal · 2017Article
- Frequency of antibiotic associated diarrhea caused byGastroenterology and hepatology from bed to bench · 2017Article
- Proton Pump Inhibitors Do Not Increase Risk for Clostridium difficile Infection in the Intensive Care Unit.The American journal of gastroenterology · 2016Article
- The Burden of Clostridium difficile after Cervical Spine Surgery.Global spine journal · 2016Article
- Proton pump inhibitors increase the risk for hospital-acquired Clostridium difficile infection in critically ill patients.Critical care (London, England) · 2014Article
- Cost-effectiveness analysis of fidaxomicin versus vancomycin in Clostridium difficile infection.The Journal of antimicrobial chemotherapy · 2014Article
- Clostridium difficile colitis acquired in the intensive care unit: outcome and prognostic factors.Infection · 2014Article
- ICU-Onset Clostridium difficile infection in a university hospital in China: a prospective cohort study.PloS one · 2014Article
- Predictors of Clostridium difficile infection severity in patients hospitalised in medical intensive care.World journal of gastroenterology · 2013Article
- Clostridium difficile colitis in patients undergoing lower-extremity arthroplasty: rare infection with major impact.Clinical orthopaedics and related research · 2013Article
- Clostridium difficile infection is associated with increased risk of death and prolonged hospitalization in children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- [Surface disinfection in the context of infection prevention in intensive care units].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2013Review
- Clostridium difficile Associated Disease in a Neurointensive Care Unit.Frontiers in neurology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Clostridium difficile infection (CDI) management has become more daunting over the past decade because of alarming increases in CDI incidence and severity both in the hospital and in the community. This increase has concomitantly caused significant escalation of the health-care economic burden caused by CDI, and it will likely be translated to increased ICU admission and attributable mortality. Some possible causes for difficulty in management of CDI are as follows: (1) inability to predict and prevent development of severe/complicated or relapsing CDI in patients who initially present with mild symptoms; (2) lack of a method to determine who would have benefited a priori from initiating vancomycin treatment first instead of treatment with metronidazole; (3) lack of sensitive and specific CDI diagnostics; (4) changing epidemiology of CDI, including the emergence of a hypervirulent, epidemic C difficile strain associated with increased morbidity and mortality; (5) association of certain high-usage nonantimicrobial medications with CDI; and (6) lack of treatment regimens that leave the normal intestinal flora undisturbed while treating the primary infection. The objective of this article is to present current management and prevention guidelines for CDI based on recommendations by the Society for Healthcare Epidemiology of America and Infectious Diseases Society of America and potential new clinical management strategies on the horizon.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.