ArticleThe Journal of infectious diseases2012
Impaired wound healing predisposes obese mice to severe influenza virus infection.
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- The healthy Nordic diet for blood glucose control: a systematic review and meta-analysis of randomized controlled clinical trials.Acta diabetologica · 2020Pooled it
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- Sex Differences in the Impact of Obesity on Immunity.Immunological reviews · 2026Review
- Body Size and Risk of Death During the 1918 Influenza Pandemic in Alaska.American journal of human biology : the official journal of the Human Biology Council · 2025Article
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- Metabolic syndrome enhances SARS-CoV-2 disease severity and reduces mRNA vaccine efficacy in a mouse model.bioRxiv : the preprint server for biology · 2025Article
- Diabetes exacerbates SARS-CoV-2 replication through ineffective pulmonary interferon responses, delayed cell-mediated immunity, and disruption of leptin signaling.Frontiers in cellular and infection microbiology · 2025Article
- Age, comorbidity burden and late presentation are significant predictors of hospitalization length and acute respiratory failure in patients with influenza.Scientific reports · 2024Article
- Diet-induced obesity affects influenza disease severity and transmission dynamics in ferrets.Science advances · 2024Article
- The Impact of Obesity on the Host-Pathogen Interaction with Influenza Viruses - Novel Insights: Narrative Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Inhibition of angiogenesis and regenerative lung growth inFrontiers in cardiovascular medicine · 2024Article
- Obesity amplifies influenza virus-driven disease severity in male and female mice.Mucosal immunology · 2023Article
- Diet-induced obesity and diabetes enhance mortality and reduce vaccine efficacy for SARS-CoV-2.Journal of virology · 2023Article
- Article
- Orthopedic Manifestations and Post-COVID-19 Infection.Journal of pharmacy & bioallied sciences · 2023Article
- Controlling viral inflammatory lesions by rebalancing immune response patterns.Frontiers in immunology · 2023Review
- Disease tolerance: a protective mechanism of lung infections.Frontiers in cellular and infection microbiology · 2023Review
- Obesity exacerbates influenza-induced respiratory disease via the arachidonic acid-p38 MAPK pathway.Frontiers in pharmacology · 2023Article
- Body Mass Index and Risk for COVID-19-Related Hospitalization in Adults Aged 50 and Older in Europe.Nutrients · 2022Article
- Influenza antivirals and animal models.FEBS open bio · 2022Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
For the first time, obesity appeared as a risk factor for developing severe 2009 pandemic influenza infection. Given the increase in obesity, there is a need to understand the mechanisms underlying poor outcomes in this population. In these studies, we examined the severity of pandemic influenza virus in obese mice and evaluated antiviral effectiveness. We found that genetically and diet-induced obese mice challenged with either 2009 influenza A virus subtype H1N1 or 1968 subtype H3N2 strains were more likely to have increased mortality and lung pathology associated with impaired wound repair and subsequent pulmonary edema. Antiviral treatment with oseltamivir enhanced survival of obese mice. Overall, these studies demonstrate that impaired wound lung repair in the lungs of obese animals may result in severe influenza virus infection. Alternative approaches to prevention and control of influenza may be needed in the setting of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.