Trial reportThe Journal of infectious diseases2012
Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda.
Trial report in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Association between male circumcision and women's biomedical health outcomes: a systematic review.The Lancet. Global health · 2017Pooled it
- Interventions for men and women with their first episode of genital herpes.The Cochrane database of systematic reviews · 2016Pooled it
- Association between male circumcision and incidence of syphilis in men and women: a prospective study in HIV-1 serodiscordant heterosexual African couples.The Lancet. Global health · 2014Trial
- Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?Frontiers in public health · 2019Article
- Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (full version).Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Article
- Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (abridged version).Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Article
- Critical evaluation of unscientific arguments disparaging affirmative infant male circumcision policy.World journal of clinical pediatrics · 2016Article
- Herpes Simplex [corrected] Virus Type 2 Shedding From Male Circumcision Wounds in Rakai, Uganda.The Journal of infectious diseases · 2015Observational
- Prevalence and incidence estimation of HSV-2 by two IgG ELISA methods among South African women at high risk of HIV.PloS one · 2015Article
- Incidence of herpes simplex virus type 2 infections in Africa: a systematic review.Open forum infectious diseases · 2014Review
- Transient antibody-mucin interactions produce a dynamic molecular shield against viral invasion.Biophysical journal · 2014Article
- Article
- Male circumcision: a globally relevant but under-utilized method for the prevention of HIV and other sexually transmitted infections.Annual review of medicine · 2014Review
- Incident HSV-2 infections are common among HIV-1-discordant couples.The Journal of infectious diseases · 2013Article
- Low frequency of male circumcision and unwillingness to be circumcised among MSM in Buenos Aires, Argentina: association with sexually transmitted infections.Journal of the International AIDS Society · 2013Article
- Rapid host immune response and viral dynamics in herpes simplex virus-2 infection.Nature medicine · 2013Article
- Voluntary medical male circumcision: an HIV prevention priority for PEPFAR.Journal of acquired immune deficiency syndromes (1999) · 2012Review
- Male circumcision and Sexually transmitted Infections - An update.Indian journal of sexually transmitted diseases and AIDSReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Male circumcision reduces acquisition of herpes simplex virus type 2 (HSV-2) in men. We assessed whether male circumcision reduces HSV-2 infection among female partners. HSV-2-negative, human immunodeficiency virus-negative female partners of 368 males who were and 372 males who were not randomized to receive male circumcision were enrolled. The incidence of HSV-2 infection among females over a period of 2 years was 6.09 cases per 100 person-years in the intervention arm and 6.32 cases per 100 person-years in the control arm (incidence rate ratio [IRR], 0.96 [95% confidence interval {CI}, .62-1.49]; P = .87). Among female partners of HSV-2-positive males, the incidence of HSV-2 infection was 9.55 cases per 100 person-years in the intervention arm and 11.17 cases per 100 person-years in the control arm (IRR, 0.85 [95% CI, .44-1.67]; P = .62). Contrary to findings in males, male circumcision did not affect HSV-2 acquisition among female partners.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.