Evidence map›Paper›PMID 22147701›Full record

ReviewThe Journal of biological chemistry2012

Regulation by S-nitrosylation of protein post-translational modification.

Douglas T Hess, Jonathan S Stamler

Abstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Intracellular Crosstalk of the Gasotransmitter Trio (NO, CO, HInternational journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Nitric oxide tunes secreted metabolite bioactivity.bioRxiv : the preprint server for biology · 2025
    Article
  10. Review
  11. S-nitrosylation of pVHL regulates βProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Douglas T HessInstitute for Transformative Molecular Medicine and Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Jonathan S Stamler

Funding

Regulation of Beta-Adrenergic Receptor Signaling by S-NitrosylationP01HL075443 · NHLBI · DUKE UNIVERSITY · PI STAMLER, JONATHAN S. · 2004 to 2019
$26.1M
Redox Signalling by Nitric Oxide in Skeletal MuscleR01HL059130 · NHLBI · DUKE UNIVERSITY · PI STAMLER, JONATHAN S. · 1997 to 2011
$3.1M
Red Blood Cell S-nitrosothiols and OxygenationR01HL091876 · NHLBI · DUKE UNIVERSITY · PI STAMLER, JONATHAN S. · 2009 to 2012
$1.6M
Restoration and Function of S-nitrosothiol in Stored BloodR01HL095463 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STAMLER, JONATHAN S. · 2009 to 2012
$1.5M
NHLBI NIH HHS P01 HL075443NHLBI NIH HHS P01HL75443NHLBI NIH HHS R01 HL059130NHLBI NIH HHS R01HL059130NHLBI NIH HHS R01 HL091876NHLBI NIH HHS R01HL091876NHLBI NIH HHS R01 HL095463NHLBI NIH HHS R01HL095463
6 · The paper itself

Abstract

Protein post-translational modification by S-nitrosylation conveys a ubiquitous influence of nitric oxide on signal transduction in eukaryotic cells. The wide functional purview of S-nitrosylation reflects in part the regulation by S-nitrosylation of the principal protein post-translational modifications that play a role in cell signaling, including phosphorylation, acetylation, ubiquitylation and related modifications, palmitoylation, and alternative Cys-based redox modifications. In this minireview, we discuss the mechanisms through which S-nitrosylation exerts its broad pleiotropic influence on protein post-translational modification.

Indexed as

AcetylationAnimalsHumansNitric OxidePhosphorylationProtein Processing, Post-TranslationalSignal TransductionNitric Oxide

Identifiers

PMID22147701
PMCPMC3281651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.