ArticleEMBO molecular medicine2012
The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis.
Article in EMBO molecular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 87 citations in OpenAlex.
- Wntless degradation mediated by CaMKII inhibition drives endoplasmic reticulum stress and apoptosis.Cell reports · 2026Article
- Review
- Article
- The role of Evi/Wntless in exporting Wnt proteins.Development (Cambridge, England) · 2023Review
- Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale.Journal of medicinal chemistry · 2022Review
- Glioblastoma Stem Cells-Useful Tools in the Battle against Cancer.International journal of molecular sciences · 2022Review
- WNT signaling at the intersection between neurogenesis and brain tumorigenesis.Frontiers in molecular neuroscience · 2022Review
- WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.Autophagy · 2021Article
- Defining phenotypic and functional heterogeneity of glioblastoma stem cells by mass cytometry.JCI insight · 2021Article
- WLS-Wnt signaling promotes neuroendocrine prostate cancer.iScience · 2021Article
- Article
- Is There Such a Thing as a Genuine Cancer Stem Cell Marker? Perspectives from the Gut, the Brain and the Dental Pulp.Biology · 2020Review
- Wntless (Wls): A Prognostic Index for Progression and Patient Survival of Breast Cancer.OncoTargets and therapy · 2020Article
- Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells.Genes & development · 2019Article
- Wnt traffic from endoplasmic reticulum to filopodia.PloS one · 2019Article
- Wntless promotes cellular viability and resistance to enzalutamide in castration-resistant prostate cancer cells.American journal of clinical and experimental urology · 2019Article
- Prosaposin promotes the proliferation and tumorigenesis of glioma through toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway.EBioMedicine · 2018Article
- Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice.Hepatology (Baltimore, Md.) · 2018Article
- Propofol inhibits Wnt signaling and exerts anticancer activity in glioma cells.Oncology letters · 2018Article
- Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis.BMB reports · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant astrocytomas are highly aggressive brain tumours with poor prognosis. While a number of structural genomic changes and dysregulation of signalling pathways in gliomas have been described, the identification of biomarkers and druggable targets remains an important task for novel diagnostic and therapeutic approaches. Here, we show that the Wnt-specific secretory protein Evi (also known as GPR177/Wntless/Sprinter) is overexpressed in astrocytic gliomas. Evi/Wls is a core Wnt signalling component and a specific regulator of pan-Wnt protein secretion, affecting both canonical and non-canonical signalling. We demonstrate that its depletion in glioma and glioma-derived stem-like cells led to decreased cell proliferation and apoptosis. Furthermore, Evi/Wls silencing in glioma cells reduced cell migration and the capacity to form tumours in vivo. We further show that Evi/Wls overexpression is sufficient to promote downstream Wnt signalling. Taken together, our study identifies Evi/Wls as an essential regulator of glioma tumourigenesis, identifying a pathway-specific protein trafficking factor as an oncogene and offering novel therapeutic options to interfere with the aberrant regulation of growth factors at the site of production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.