ArticlePlant physiology2012
Silencing MPK4 in Nicotiana attenuata enhances photosynthesis and seed production but compromises abscisic acid-induced stomatal closure and guard cell-mediated resistance to Pseudomonas syringae pv tomato DC3000.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 95 citations in OpenAlex.
- Spatiotemporal transcriptomic and metabolomic landscapes of wild soybean seed development reveal regulatory mechanisms of nutrient accumulation.Plant communications · 2026Article
- Functional analysis of StMAPK19 gene in response to salt stress in potato (Solanum tuberosum L.).BMC plant biology · 2025Article
- NaLRR-RK4 mediates MAPK signaling to enhance plant defense against Alternaria alternata in Nicotiana attenuata.Scientific reports · 2025Article
- Salicylic acid positively regulates maize defenses against lepidopteran insects.Plant diversity · 2024Article
- Phosphorylation of MdERF17 by MdMPK4 promotes apple fruit peel degreening during light/dark transitions.The Plant cell · 2022Article
- Rapeseed (Frontiers in plant science · 2022Article
- Light dominates the diurnal emissions of herbivore-induced volatiles in wild tobacco.BMC plant biology · 2021Article
- MITOGEN-ACTIVATED PROTEIN KINASE 4 impacts leaf development, temperature, and stomatal movement in hybrid aspen.Plant physiology · 2021Article
- The effect of increasing temperature on crop photosynthesis: from enzymes to ecosystems.Journal of experimental botany · 2021Review
- Article
- In-depth proteome analysis reveals multiple pathways involved in tomato SlMPK1-mediated high-temperature responses.Protoplasma · 2020Article
- Does Molecular and Structural Evolution Shape the Speedy Grass Stomata?Frontiers in plant science · 2020Review
- Is nitric oxide a critical key factor in ABA-induced stomatal closure?Journal of experimental botany · 2020Article
- Proteomic characterization of MPK4 signaling network and putative substrates.Plant molecular biology · 2019Article
- An unbiased approach elucidates variation in (Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Exploiting natural variation and genetic manipulation of stomatal conductance for crop improvement.Current opinion in plant biology · 2019Review
- Mitogen-activated protein kinases MPK4 and MPK12 are key components mediating COThe Plant journal : for cell and molecular biology · 2018Article
- ExpressingInternational journal of molecular sciences · 2018Article
- New functions of an old kinase MPK4 in guard cells.Plant signaling & behavior · 2018Article
- Mitogen-Activated Protein Kinase Cascades in Plant Hormone Signaling.Frontiers in plant science · 2018Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitogen-activated protein kinases (MAPKs) play pivotal roles in development and environmental interactions in eukaryotes. Here, we studied the function of a MAPK, NaMPK4, in the wild tobacco species Nicotiana attenuata. The NaMPK4-silenced N. attenuata (irNaMPK4) attained somewhat smaller stature, delayed senescence, and greatly enhanced stomatal conductance and photosynthetic rate, especially during late developmental stages. All these changes were associated with highly increased seed production. Using leaf epidermal peels, we demonstrate that guard cell closure in irNaMPK4 was strongly impaired in response to abscisic acid and hydrogen peroxide, and consistently, irNaMPK4 plants transpired more water and wilted sooner than did wild-type plants when they were deprived of water. We show that NaMPK4 plays an important role in the guard cell-mediated defense against a surface-deposited bacterial pathogen, Pseudomonas syringae pv tomato (Pst) DC3000; in contrast, when bacteria directly entered leaves by pressure infiltration, NaMPK4 was found to be less important in the resistance to apoplast-located Pst DC3000. Moreover, we show that salicylic acid was not involved in the defense against PstDC3000 in wild-type and irNaMPK4 plants once it had entered leaf tissue. Finally, we provide evidence that NaMPK4 functions differently from AtMPK4 and AtMPK11 in Arabidopsis (Arabidopsis thaliana), despite their sequence similarities, suggesting a complex functional divergence of MAPKs in different plant lineages. This work highlights the multifaceted functions of NaMPK4 in guard cells and underscores its role in mediating various ecologically important traits.
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