Evidence map›Paper›PMID 22147365›Full record

Trial reportCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2012

Urinary bladder cancer risk factors in Egypt: a multicenter case-control study.

Yun-Ling Zheng, Sania Amr, Doa'a A Saleh, Chiranjeev Dash, Sameera Ezzat, Nabiel N Mikhail, Iman Gouda, Iman Loay, Tamer Hifnawy, Mohamed Abdel-Hamid and 4 more

Open access · bronzeAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Review
  11. Unveiling an Association between Waterpipe Smoking and Bladder Cancer Risk: A Multicenter Case-Control Study in Iran.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Urinary hyaluronic acid: a versatile marker of bladder cancer.International urology and nephrology · 2020
    Article
  16. Schistosomiasis and Bladder Cancer in Egypt: Truths and Myths.Open access Macedonian journal of medical sciences · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Yun-Ling ZhengCarcinogenesis, Biomarkers and Epidemiology Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA.
Sania Amr
Doa'a A Saleh
Chiranjeev Dash
Sameera Ezzat
Nabiel N Mikhail
Iman Gouda
Iman Loay
Tamer Hifnawy
Mohamed Abdel-Hamid
Hussein Khaled
Beverly Wolpert
Mohamed A Abdel-Aziz
Christopher A Loffredo
Cairo University · EGBeni-Suef University · EGUniversity of Maryland, Baltimore · USGeorgetown University · USAssiut University · EGNational Cancer Institute · US

Funding

Telomere dysfunction, chromosome 9 instability and bladder cancer riskR01CA132996 · NCI · GEORGETOWN UNIVERSITY · PI ZHENG, YUN-LING · 2009 to 2013
$2.7M
Gender Differences in Bladder Cancer Risk FactorsR01CA115618 · NCI · GEORGETOWN UNIVERSITY · PI LOFFREDO, CHRISTOPHER A · 2006 to 2010
$2.2M
NCI NIH HHS R01 CA115618NCI NIH HHS R01-CA115618NCI NIH HHS R01 CA132996NCI NIH HHS R01-CA132996
6 · The paper itself

Abstract

backgroundWe investigated associations between tobacco exposure, history of schistosomiasis, and bladder cancer risk in Egypt.

methodsWe analyzed data from a case-control study (1,886 newly diagnosed and histologically confirmed cases and 2,716 age-, gender-, and residence-matched, population-based controls). Using logistic regression, we estimated the covariate-adjusted ORs and 95% confidence interval (CI) of the associations.

resultsAmong men, cigarette smoking was associated with an increased risk of urothelial carcinoma (OR = 1.8; 95% CI, 1.4-2.2) but not squamous cell carcinoma (SCC); smoking both water pipes and cigarettes was associated with an even greater risk for urothelial carcinoma (OR = 2.9; 95% CI, 2.1-3.9) and a statistically significant risk for SCC (OR = 1.8; 95% CI, 1.2-2.6). Among nonsmoking men and women, environmental tobacco smoke exposure was associated with an increased risk of urothelial carcinoma. History of schistosomiasis was associated with increased risk of both urothelial carcinoma (OR = 1.9; 95% CI, 1.2-2.9) and SCC (OR = 1.9; 95% CI, 1.2-3.0) in women and to a lesser extent (OR = 1.4; 95% CI, 1.2-1.7 and OR = 1.4; 95% CI, 1.1-1.7, for urothelial carcinoma and SCC, respectively) in men.

conclusionsThe results suggest that schistosomiasis and tobacco smoking increase the risk of both SCC and urothelial carcinoma. IMPACT: This study provides new evidence for associations between bladder cancer subtypes and schistosomiasis and suggests that smoking both cigarettes and water pipes increases the risk for SCC and urothelial carcinoma in Egyptian men.

Indexed as

AdenocarcinomaAgedCarcinoma, Squamous CellCase-Control StudiesEgyptFemaleHumansMaleMiddle AgedSchistosomiasisTobacco Smoke PollutionUrinary Bladder NeoplasmsTobacco Smoke Pollution

Identifiers

PMID22147365
PMCPMC3297723
OpenAlexW2127875004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.