ArticleDigestive diseases and sciences2012
Emu oil increases colonic crypt depth in a rat model of ulcerative colitis.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 57 citations in OpenAlex.
- Effect of Mutant and Engineered High-Acetate-ProducingNutrients · 2024Article
- Emu Oil and zinc monoglycerolate independently reduce disease severity in a rat model of ulcerative colitis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Review
- Getting clues from nature: the impact of grass hay on suckling piglets' gastrointestinal growth and colonic microbiota.Frontiers in cellular and infection microbiology · 2023Article
- Article
- Orally administered emu oil attenuates disease in a mouse model of Crohn's-like colitis.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Dietary supplementation of micro-encapsulated sodium butyrate in healthy horses: effect on gut histology and immunohistochemistry parameters.BMC veterinary research · 2020Article
- Development and characterization of ten novel microsatellite loci for the emu (Dromaius novaehollandiae) and genetic diversity of Japanese farm populations.Molecular biology reports · 2020Article
- Affective state determination in a mouse model of colitis-associated colorectal cancer.PloS one · 2020Article
- Effect of heat-killedPeerJ · 2019Article
- Intestinal homeostasis is restored in mice following a period of intestinal growth induced by orally administered Emu Oil.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Emu Oil Improves Clinical Indicators of Disease in a Mouse Model of Colitis-Associated Colorectal Cancer.Digestive diseases and sciences · 2018Article
- Emu oil offers protection in Crohn's disease model in rats.BMC complementary and alternative medicine · 2016Article
- Amelioration of Chemotherapy-Induced Intestinal Mucositis by Orally Administered Probiotics in a Mouse Model.PloS one · 2015Article
- Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Emu oil reduces small intestinal inflammation in the absence of clinical improvement in a rat model of indomethacin-induced enteropathy.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Emu Oil: A Potential Adjunct to Inflammatory Bowel Disease Treatment?Inflammatory intestinal diseasesReview
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent treatments for the inflammatory bowel diseases, encompassing Crohn's disease and ulcerative colitis, are variably effective. Emu oil, extracted from emu fat, predominantly comprises fatty acids, with purported claims of anti-inflammatory properties.
aimWe evaluated emu oil for its potential to ameliorate dextran sulphate sodium (DSS)-induced colitis in rats.
methodsMale Sprague-Dawley Rats were allocated to treatment groups (n = 8). Groups 1 and 2 consumed water and were gavaged (1 ml) daily with water (group 1) or emu oil (group 2) from days 0 to 10. Groups 3-6 ingested 2% DSS in the drinking water from days 5 to 10 and were gavaged from days 0 to 10 with water (group 3), 0.5 ml emu oil (group 4) or 1 ml emu oil (group 5). Group 6 received 1 ml emu oil after commencing DSS treatment (days 6-10). Disease activity index, metabolic parameters, (13)C-sucrose breath test, and histological colonic damage severity and crypt depth were assessed.
resultsEmu oil in DSS-treated rats reduced colonic damage severity compared to DSS-controls (up to threefold; P < 0.001). In DSS-treated rats, crypts in the proximal colon were lengthened by 0.5 ml emu oil (373 ± 18 μm), compared with DSS-controls (302 ± 8 μm); whilst in the distal colon (DSS control: 271 ± 17 μm), crypt depth was greater following 0.5 ml emu oil (352 ± 22 μm) and 1 ml emu oil (341 ± 9 μm) and also when emu oil was administered post-DSS commencement (Group 6: 409 ± 16 μm; P < 0.05). Emu oil did not significantly affect other parameters of colonic architecture.
conclusionsEmu oil improved tissue damage associated with colitis, suggesting its potential as a unique formulation to augment conventional treatment approaches for IBD.
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