ReviewMammalian genome : official journal of the International Mammalian Genome Society2012
Canine models of copper toxicosis for understanding mammalian copper metabolism.
Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Case Report: Fatal copper-associated hepatopathy in a Belgian Shepherd Malinois dog initially investigated as suspected malicious poisoning.Frontiers in veterinary science · 2026Article
- Copper metabolism and its implications for canine nutrition.Translational animal science · 2024Review
- Relationships between the Content of Micro- and Macroelements in Animal Samples and Diseases of Different Etiologies.Animals : an open access journal from MDPI · 2023Article
- Pedigree study of the heredity of copper-associated hepatitis in Dalmatians in Japan.The Canadian veterinary journal = La revue veterinaire canadienne · 2022Article
- The Rat Genome Database (RGD) facilitates genomic and phenotypic data integration across multiple species for biomedical research.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- Copper-associated hepatitis in a young Dalmatian dog in Japan.The Journal of veterinary medical science · 2021Article
- Assessment of copper accumulation in archived liver specimens from cats.Journal of feline medicine and surgery · 2021Article
- D-Penicillamine: The State of the Art in Humans and in Dogs from a Pharmacological and Regulatory Perspective.Antibiotics (Basel, Switzerland) · 2021Review
- Mineral Composition of Cereal and Cereal-Free Dry Dog Foods versus Nutritional Guidelines.Molecules (Basel, Switzerland) · 2020Article
- Serum Concentrations of Essential Trace and Toxic Elements in Healthy and Disease-Affected Dogs.Animals : an open access journal from MDPI · 2020Article
- Association of the canine ATP7A and ATP7B with hepatic copper accumulation in Dobermann dogs.Journal of veterinary internal medicine · 2019Article
- Ingestion of bedding material as a cause of acute copper sulfate poisoning in turkey poults.Poultry science · 2019Article
- Animal models of Wilson disease.Journal of neurochemistry · 2018Review
- CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.Nature communications · 2016Article
- Canine Models for Copper Homeostasis Disorders.International journal of molecular sciences · 2016Review
- The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders.Disease models & mechanisms · 2016Article
- Article
- Distinct phenotype of a Wilson disease mutation reveals a novel trafficking determinant in the copper transporter ATP7B.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hereditary forms of copper toxicosis exist in man and dogs. In man, Wilson's disease is the best studied disorder of copper overload, resulting from mutations in the gene coding for the copper transporter ATP7B. Forms of copper toxicosis for which no causal gene is known yet are recognized as well, often in young children. Although advances have been made in unraveling the genetic background of disorders of copper metabolism in man, many questions regarding disease mechanisms and copper homeostasis remain unanswered. Genetic studies in the Bedlington terrier, a dog breed affected with copper toxicosis, identified COMMD1, a gene that was previously unknown to be involved in copper metabolism. Besides the Bedlington terrier, a number of other dog breeds suffer from hereditary copper toxicosis and show similar phenotypes to humans with copper storage disorders. Unlike the heterogeneity of most human populations, the genetic structure within a purebred dog population is homogeneous, which is advantageous for unraveling the molecular genetics of complex diseases. This article reviews the work that has been done on the Bedlington terrier, summarizes what was learned from studies into COMMD1 function, describes hereditary copper toxicosis phenotypes in other dog breeds, and discusses the opportunities for genome-wide association studies on copper toxicosis in the dog to contribute to the understanding of mammalian copper metabolism and copper metabolism disorders in man.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.