ReviewIntensive care medicine2012
Contemporary extracorporeal membrane oxygenation for adult respiratory failure: life support in the new era.
Review in Intensive care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
163 citing papers in PubMed, 6 syntheses or guidelines pooled it, 408 citations in OpenAlex.
- Impact of Extracorporeal Membrane Oxygenation Life Support on Vancomycin Population Pharmacokinetics in Critical Illness: A Systematic Review.Clinical drug investigation · 2025Pooled it
- Hospital-acquired infections in neonatal ECMO patients: a systematic review and meta-analysis.Italian journal of pediatrics · 2025Pooled it
- Pooled it
- Mechanical ventilation during extracorporeal life support (ECLS): a systematic review.Intensive care medicine · 2015Pooled it
- Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review.Critical care (London, England) · 2015Pooled it
- Extracorporeal membrane oxygenation for critically ill adults.The Cochrane database of systematic reviews · 2015Pooled it
- Population Pharmacokinetics of Intravenous Infusion of Hydromorphone in Critically Ill Patients Supported by Extracorporeal Membrane Oxygenation.Clinical and translational science · 2026Trial
- Population pharmacokinetics of remifentanil in critically ill patients receiving extracorporeal membrane oxygenation.Scientific reports · 2017Trial
- Serum S100B protein could help to detect cerebral complications associated with extracorporeal membrane oxygenation (ECMO).Neurocritical care · 2014Trial
- The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome.Intensive care medicine · 2013Trial
- From Fiber Bundles to Architected Membranes: Triply Periodic Minimal Surface Architectures for Biohybrid Artificial Lungs.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Consensus on the use of extracorporeal membrane oxygenation during the perioperative period of lung transplantation.World journal of emergency medicine · 2026Article
- Magnetostaltic pumping in an ex vivo extracorporeal membrane oxygenation model.Journal of translational medicine · 2026Article
- Observational
- Evolution of extracorporeal membrane oxygenation: historical milestones and advanced developments.The journal of extra-corporeal technology · 2025Review
- Nutrition Provision in Pediatric Extracorporeal Membrane Oxygenation: Evidence, Challenges, and Clinical Considerations.Nutrients · 2025Review
- A Novel Valveless Pulsatile Flow Pump for Extracorporeal Blood Circulation.Annals of biomedical engineering · 2025Article
- Five-day Wearable Respiratory Support With a Novel Ambulatory Pulmonary Assist System in an Awake Ovine Model.Transplantation · 2025Article
- Comparison of integrated versus parallel continuous renal replacement therapy combined with veno-venous extracorporeal membrane oxygenation in patients with COVID-19 ARDS.BMC anesthesiology · 2025Article
- Case Report: A case of severe viral pneumonia complicated by pulmonary embolism treated with extracorporeal membrane oxygenation combined with interventional thrombectomy.Frontiers in cardiovascular medicine · 2025Article
103 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtracorporeal membrane oxygenation (ECMO) has been used in clinical medicine for 40 years but remains controversial therapy, particularly in adult patients with severe respiratory failure. Over the last few years, there have been considerable advances in extracorporeal technology and clinical practice, ushering in a new era of ECMO. Many institutions adopted ECMO as rescue therapy during the recent H1N1 influenza pandemic, reigniting the controversy. DISCUSSION: Hollow-fibre oxygenators and Mendler-designed centrifugal pumps have replaced the old silicon oxygenators and roller pumps. The advantages of these novel systems and the principles that underlie their function are outlined. Advances in cannula technology allow greater ease of patient positioning, in some cases facilitating extubation and ambulation on ECMO. Improvements in ECMO circuitry have led to a reduction in heparin and blood product requirements, with consequently fewer complications. Greater understanding of severe acute respiratory distress syndrome has allowed clinicians to successfully support adults on ECMO for months at a time, as a bridge to either recovery or transplantation.
conclusionsECMO is safer, cheaper, and simpler than in previous eras. Both circuit and patient can be cared for by a single trained nurse. Additional prospective studies of ECMO for adult respiratory failure are underway. Contemporary ECMO in awake, potentially ambulant patients to provide short-term support for those with acute, reversible respiratory failure and as a bridge to transplantation in those with irreversible respiratory failure is now ready for widespread evaluation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.