ArticleBreast cancer research and treatment2012
Evaluating breast cancer risk projections for Hispanic women.
Article in Breast cancer research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of performance of the Gail model for predicting breast cancer risk: a systematic review and meta-analysis with trial sequential analysis.Breast cancer research : BCR · 2018Pooled it
- Perceptions of the Acceptability of Community-Based Breast Cancer Risk Assessment among Underserved Latinas in Maricopa County, Arizona.Journal of racial and ethnic health disparities · 2026Article
- Evaluating the Gail Model: Racial Disparities in Breast Cancer Risk Assessment.Annals of surgical oncology · 2026Article
- Understanding Benign Breast Disease and Subsequent Breast Cancer in Hispanic White Females: A Step Closer to Evidence-Based Management.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Breast cancer risk prediction combining a convolutional neural network-based mammographic evaluation with clinical factors.Breast cancer research and treatment · 2023Article
- Review
- Risk Models for Breast Cancer and Their Validation.Statistical science : a review journal of the Institute of Mathematical Statistics · 2020Article
- Comparative Validation of Breast Cancer Risk Prediction Models and Projections for Future Risk Stratification.Journal of the National Cancer Institute · 2020Article
- Review of non-clinical risk models to aid prevention of breast cancer.Cancer causes & control : CCC · 2018Review
- Development of a Cancer Risk Prediction Tool for Use in the UK Primary Care and Community Settings.Cancer prevention research (Philadelphia, Pa.) · 2017Article
- Projecting Individualized Absolute Invasive Breast Cancer Risk in US Hispanic Women.Journal of the National Cancer Institute · 2017Article
- SNPs and breast cancer risk prediction for African American and Hispanic women.Breast cancer research and treatment · 2015Article
- Development of a risk assessment tool for projecting individualized probabilities of developing breast cancer for Chinese women.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Perceived versus objective breast cancer risk in diverse women.Journal of women's health (2002) · 2014Article
- An assessment of existing models for individualized breast cancer risk estimation in a screening program in Spain.BMC cancer · 2013Article
- The risk of developing invasive breast cancer in Hispanic women : a look across Hispanic subgroups.Cancer · 2013Article
- Personalized medicine and access to health care: potential for inequitable access?European journal of human genetics : EJHG · 2013Article
- Recalibration of the Gail model for predicting invasive breast cancer risk in Spanish women: a population-based cohort study.Breast cancer research and treatment · 2013Article
- Establishing a program for individuals at high risk for breast cancer.Journal of Cancer · 2013Article
- Perceived and objective breast cancer risk assessment in Chilean women living in an underserved area.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
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Authors and funding
10 authors.
Funding
Abstract
For Hispanic women, the Breast Cancer Risk Assessment Tool (BCRAT; "Gail Model") combines 1990-1996 breast cancer incidence for Hispanic women with relative risks for breast cancer risk factors from non-Hispanic white (NHW) women. BCRAT risk projections have never been comprehensively evaluated for Hispanic women. We compared the relative risks and calibration of BCRAT risk projections for 6,353 Hispanic to 128,976 NHW postmenopausal participants aged 50 and older in the Women's Health Initiative (WHI). Calibration was assessed by the ratio of the number of breast cancers observed with that expected by the BCRAT (O/E). We re-evaluated calibration for an updated BCRAT that combined BCRAT relative risks with 1993-2007 breast cancer incidence that is contemporaneous with the WHI. Cox regression was used to estimate relative risks. Discriminatory accuracy was assessed using the concordance statistic (AUC). In the WHI Main Study, the BCRAT underestimated the number of breast cancers by 18% in both Hispanics (O/E = 1.18, P = 0.06) and NHWs (O/E = 1.18, P < 0.001). Updating the BCRAT improved calibration for Hispanic women (O/E = 1.08, P = 0.4) and NHW women (O/E = 0.98, P = 0.2). For Hispanic women, relative risks for number of breast biopsies (1.71 vs. 1.27, P = 0.03) and age at first birth (0.97 vs. 1.24, P = 0.02) differed between the WHI and BCRAT. The AUC was higher for Hispanic women than NHW women (0.63 vs. 0.58, P = 0.03). Updating the BCRAT with contemporaneous breast cancer incidence rates improved calibration in the WHI. The modest discriminatory accuracy of the BCRAT for Hispanic women might improve by using risk factor relative risks specific to Hispanic women.
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