ArticleTransgenic research2012
Overexpression of the wild potato eIF4E-1 variant Eva1 elicits Potato virus Y resistance in plants silenced for native eIF4E-1.
Article in Transgenic research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Imprecise Cas12a/ssODN-Mediated Editing of eIF4E1 Confers Dominant-Negative Resistance to Potato Virus Y in Solanum tuberosum.Molecular plant pathology · 2026Article
- Molecular gatekeepers: eukaryotic translation factors decoding plant-virus dynamics for resistance engineering.Stress biology · 2026Review
- Editing metacaspase (StMC7) gene enhances late blight resistance in Russet Burbank potato.PloS one · 2025Article
- A natural substitution of a conserved amino acid in eIF4E confers resistance against multiple potyviruses.Molecular plant pathology · 2024Article
- Genome editing (CRISPR-Cas)-mediated virus resistance in potato (Solanum tuberosum L.).Molecular biology reports · 2022Review
- Genome-Wide Identification and Expression Analysis of eIF Family Genes fromPlants (Basel, Switzerland) · 2022Article
- CRISPR/Cas9-Mediated Targeting of Susceptibility FactorFrontiers in genetics · 2022Article
- CRISPR-Cas9 Targeting of theFrontiers in microbiology · 2022Article
- Variability in the Viral Protein Linked to the Genome of Turnip Mosaic Virus Influences Interactions withThe plant pathology journal · 2021Article
- The caffeoyl-CoA O-methyltransferase gene SNP replacement in Russet Burbank potato variety enhances late blight resistance through cell wall reinforcement.Plant cell reports · 2021Article
- Evaluation of Plant-Derived Promoters for Constitutive and Tissue-Specific Gene Expression in Potato.Plants (Basel, Switzerland) · 2020Article
- Prospects for potato genome editing to engineer resistance against viruses and cold-induced sweetening.GM crops & food · 2020Review
- Overexpression of a modified eIF4E regulates potato virus Y resistance at the transcriptional level in potato.BMC genomics · 2020Article
- Manipulating Cellular Factors to Combat Viruses: A Case Study From the Plant Eukaryotic Translation Initiation Factors eIF4.Frontiers in microbiology · 2019Review
- Mutations in eIF5B Confer Thermosensitive and Pleiotropic Phenotypes via Translation Defects inThe Plant cell · 2017Article
- Back into the wild-Apply untapped genetic diversity of wild relatives for crop improvement.Evolutionary applications · 2017Review
- Engineering of CRISPR/Cas9-mediated potyvirus resistance in transgene-free Arabidopsis plants.Molecular plant pathology · 2016Article
- Plant Translation Factors and Virus Resistance.Viruses · 2015Review
- Transgenic Brassica rapa plants over-expressing eIF(iso)4E variants show broad-spectrum Turnip mosaic virus (TuMV) resistance.Molecular plant pathology · 2014Article
- Detection of the virulent form of AVR3a from Phytophthora infestans following artificial evolution of potato resistance gene R3a.PloS one · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Potato virus Y (PVY) is the most important viral pathogen of cultivated potato (Solanum tuberosum) from a commercial perspective, causing severe losses in both tuber quality and yield worldwide. Specific accessions of wild potato species exhibit resistance against PVY but efforts to transfer the trait to cultivated material have not yielded widely adopted varieties. Because amino acid substitutions at specific domains of host factor eIF4E-1 often confer resistance to various crops, we sequenced the associated genes expressed in wild potato plants. A novel eIF4E-1 variant, designated here as Eva1, was identified in S. chacoense, S. demissum, and S. etuberosum. The protein contains amino acid substitutions at ten different positions when compared to its cultivated potato (S. tuberosum) homolog. In the yeast two-hybrid system, Eva1 failed to bind VPg, a viral protein required for infectivity. Overexpression of the associated cDNA conferred PVY resistance to transgenic potato plants silenced for the native eIF4E-1 gene. Because the gene sources of Eva1 are sexually compatible with potato, the molecular strategies described can be employed to develop 'intragenic' potato cultivars.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.