Evidence map›Paper›PMID 22146851›Full record

ReviewVeterinary pathology2012

3-dimensional imaging modalities for phenotyping genetically engineered mice.

K A Powell, D Wilson

Abstract readReview
In one paragraph

Review in Veterinary pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Morphometrics, 3D Imaging, and Craniofacial Development.Current topics in developmental biology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

K A PowellSmall Animal Imaging Shared Resource, The James Comprehensive Cancer Center Department of Biomedical Informatics, Ohio State University, Columbus, Ohio, USA. kimerly.powell@osumc.edu
D Wilson

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Whole Mouse Cryo-ImagingR42CA124270 · NCI · BIOINVISION, INC. · PI WILSON, DAVID LYNN · 2008 to 2009
$1.5M
Coronary Plaque Characterization with Vascular OCT ImagingR21HL108263 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI COSTA, MARCO A, WILSON, DAVID LYNN · 2011 to 2012
$423k
In Vivo Assessment of Embryonic Stem Cell Teratoma PreventionR41HD063241 · NICHD · BIOINVISION, INC. · PI VON RECUM, HORST A. · 2010 to 2010
$248k
NCI NIH HHS P30 CA016058NCI NIH HHS P30CA016058NCI NIH HHS R42 CA124270NCI NIH HHS R42-CA124270NHLBI NIH HHS R21 HL108263NHLBI NIH HHS R21HL108263NICHD NIH HHS R41 HD063241NICHD NIH HHS R41HD063241
6 · The paper itself

Abstract

A variety of 3-dimensional (3D) digital imaging modalities are available for whole-body assessment of genetically engineered mice: magnetic resonance microscopy (MRM), X-ray microcomputed tomography (microCT), optical projection tomography (OPT), episcopic and cryoimaging, and ultrasound biomicroscopy (UBM). Embryo and adult mouse phenotyping can be accomplished at microscopy or near microscopy spatial resolutions using these modalities. MRM and microCT are particularly well-suited for evaluating structural information at the organ level, whereas episcopic and OPT imaging provide structural and functional information from molecular fluorescence imaging at the cellular level. UBM can be used to monitor embryonic development longitudinally in utero. Specimens are not significantly altered during preparation, and structures can be viewed in their native orientations. Technologies for rapid automated data acquisition and high-throughput phenotyping have been developed and continually improve as this exciting field evolves.

Indexed as

Mice, TransgenicPhenotypeAnimalsDiagnostic ImagingEmbryo, MammalianGenetic EngineeringHumansImaging, Three-DimensionalMiceModels, AnimalWhole Body Imaging

Identifiers

PMID22146851
PMCPMC3857693

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.