ArticleAdvances in space research : the official journal of the Committee on Space Research (COSPAR)2008
Description of International Caenorhabditis elegans Experiment first flight (ICE-FIRST).
Article in Advances in space research : the official journal of the Committee on Space Research (COSPAR), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Defining Microbiome Impact on Host Physiology During Spaceflight Using Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism.NPJ microgravity · 2024Review
- Spaceflight Induces Strength Decline inCells · 2023Article
- Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the NematodeInternational journal of molecular sciences · 2023Article
- Article
- Comparative Transcriptomics Identifies Neuronal and Metabolic Adaptations to Hypergravity and Microgravity iniScience · 2020Article
- Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments.Astrobiology · 2020Article
- Gene expression studies using a miniaturized thermal cycler system on board the International Space Station.PloS one · 2018Article
- Fluid dynamics alterNPJ microgravity · 2016Article
- Article
- Changes in apoptotic microRNA and mRNA expression profiling in Caenorhabditis elegans during the Shenzhou-8 mission.Journal of radiation research · 2015Article
- Reproductive and locomotory capacities of Caenorhabditis elegans were not affected by simulated variable gravities and spaceflight during the Shenzhou-8 mission.Astrobiology · 2013Article
- Evaluation of the Fluids Mixing Enclosure System for Life Science Experiments During a CommercialAdvances in space research : the official journal of the Committee on Space Research (COSPAR) · 2013Article
- Remote automated multi-generational growth and observation of an animal in low Earth orbit.Journal of the Royal Society, Interface · 2012Article
- Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.Scientific reports · 2012Article
- Review of the results from the International C. elegans first experiment (ICE-FIRST).Advances in space research : the official journal of the Committee on Space Research (COSPAR) · 2009Article
- Comparative analysis of Drosophila melanogaster and Caenorhabditis elegans gene expression experiments in the European Soyuz flights to the International Space Station.Advances in space research : the official journal of the Committee on Space Research (COSPAR) · 2007Article
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
Traveling, living and working in space is now a reality. The number of people and length of time in space is increasing. With new horizons for exploration it becomes more important to fully understand and provide countermeasures to the effects of the space environment on the human body. In addition, space provides a unique laboratory to study how life and physiologic functions adapt from the cellular level to that of the entire organism. Caenorhabditis elegans is a genetic model organism used to study physiology on Earth. Here we provide a description of the rationale, design, methods, and space culture validation of the ICE-FIRST payload, which engaged C. elegans researchers from four nations. Here we also show C. elegans growth and development proceeds essentially normally in a chemically defined liquid medium on board the International Space Station (10.9 day round trip). By setting flight constraints first and bringing together established C. elegans researchers second, we were able to use minimal stowage space to successfully return a total of 53 independent samples, each containing more than a hundred individual animals, to investigators within one year of experiment concept. We believe that in the future, bringing together individuals with knowledge of flight experiment operations, flight hardware, space biology, and genetic model organisms should yield similarly successful payloads.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.