ArticleJournal of cardiovascular computed tomography
Myocardial hypo-enhancement on resting computed tomography angiography images accurately identifies myocardial hypoperfusion.
Article in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Coronary inflammation on chest computed tomography and COVID-19 mortality.European radiology · 2024Article
- Complementary role of computed tomography angiography with fixed perfusion defects on SPECT myocardial perfusion imaging.European journal of hybrid imaging · 2022Article
- Myocardial computed tomography perfusion.Cardiovascular diagnosis and therapy · 2017Review
- Highly sensitive troponin and coronary computed tomography angiography in the evaluation of suspected acute coronary syndrome in the emergency department.European heart journal · 2016Review
- Evaluation of static and dynamic perfusion cardiac computed tomography for quantitation and classification tasks.Journal of medical imaging (Bellingham, Wash.) · 2016Article
- Noninvasive physiologic assessment of coronary stenoses using cardiac CT.BioMed research international · 2015Review
- Role of non-electrocardiogram-gated contrast-enhanced computed tomography in the diagnosis of acute coronary syndrome.Heart and vessels · 2015Article
- Cardiac CT for myocardial ischaemia detection and characterization--comparative analysis.The British journal of radiology · 2014Review
- Early defects identified by computed tomography angiography are associated with left ventricular dysfunction and exercise intolerance following acute myocardial infarction.Japanese journal of radiology · 2014Article
- Comparison of blood flow models and acquisitions for quantitative myocardial perfusion estimation from dynamic CT.Physics in medicine and biology · 2014Article
- Simulation Evaluation of Quantitative Myocardial Perfusion Assessment from Cardiac CT.Proceedings of SPIE--the International Society for Optical Engineering · 2014Article
- Myocardial perfusion imaging with cardiac computed tomography: state of the art.Journal of cardiovascular translational research · 2013Review
- Diagnostic performance of resting CT myocardial perfusion in patients with possible acute coronary syndrome.AJR. American journal of roentgenology · 2013Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe objective of this study was to test the diagnostic accuracy of myocardial CT perfusion (CTP) imaging using color and gray-scale image analysis.
backgroundCurrent myocardial CTP techniques have varying diagnostic accuracy and are prone to artifacts that impair detection. This study evaluated the diagnostic accuracy of color and/or gray-scale CTP and the application of artifact criteria to detect hypoperfusion.
methodsFifty-nine prospectively enrolled patients with abnormal single-photon emission computed tomography (SPECT) studies were analyzed. True hypoperfusion was defined if SPECT hypoperfusion corresponded to obstructive coronary stenoses on CT angiography (CTA). CTP applied color and gray-scale myocardial perfusion maps to resting CTA images. Criteria for identifying artifacts were also applied during interpretation.
resultsUsing combined SPECT plus CTA as the diagnostic standard, abnormal myocardial CTP was present in 33 (56%) patients, 19 suggesting infarction and 14 suggesting ischemia. Patient-level color and gray-scale myocardial CTP sensitivity to detect infarction was 90%, with specificity 80%, and negative and positive predictive value of 94% and 68%. To detect ischemia or infarction, CTP specificity and positive predictive value were 92% whereas sensitivity was 70%. Gray-scale myocardial CTP had slightly lower specificity but similar sensitivity. Myocardial CTP artifacts were present in 88% of studies and were identified using our criteria.
conclusionsColor and gray-scale myocardial CTP using resting CTA images identified myocardial infarction with high sensitivity as well as infarction or ischemia with high specificity and positive predictive value without additional testing or radiation. Color and gray-scale CTP had slightly better specificity than gray-scale alone.
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