ArticleReproductive toxicology (Elmsford, N.Y.)2012
Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay.
Article in Reproductive toxicology (Elmsford, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- The differences in levels of poly- and perfluoroalkyl substances (PFASs) in the hair of wild terrestrial mammals with various feeding behaviour.Scientific reports · 2026Article
- Antimalarial efficacy of aqueous crude rootbark extracts ofResearch square · 2026Article
- Integrated metagenomic and metabolomic analyses reveal tenacissoside G as a potential non-antimicrobial treatment for bovine endometritis.Microbiome · 2025Article
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- Per- and Polyfluoroalkyl Substances in Eutopic Endometrium Tissue and Risk of Endometriosis: Findings from the Investigating Mixtures of Pollutants and Endometriosis in Tissue (IMPLANT) Study.Environmental health perspectives · 2025Article
- Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation.Frontiers in immunology · 2025Article
- Review
- Article
- PFOA-Induced Ovotoxicity Differs Between Lean and Obese Mice With Impacts on Ovarian Reproductive and DNA Damage Sensing and Repair Proteins.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays.Toxicology and applied pharmacology · 2022Article
- Perfluoroalkyl Substances and Incident Natural Menopause in Midlife Women: The Mediating Role of Sex Hormones.American journal of epidemiology · 2022Article
- Perfluorooctanoic acid exposure in early pregnancy induces oxidative stress in mice uterus and liver.Environmental science and pollution research international · 2021Article
- Article
- Risk to human health related to the presence of perfluoroalkyl substances in food.EFSA journal. European Food Safety Authority · 2020Article
- Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women's Health Across the Nation.The Journal of clinical endocrinology and metabolism · 2020Article
- Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances.International journal of environmental research and public health · 2020Review
- Chemical-PDMS binding kinetics and implications for bioavailability in microfluidic devices.Lab on a chip · 2019Article
- Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food.EFSA journal. European Food Safety Authority · 2018Article
- Perfluorooctanoic acid exposure during pregnancy alters the apoptosis of uterine cells in pregnant mice.International journal of clinical and experimental pathology · 2018Article
- Programming of metabolic effects in C57BL/6JxFVB mice by in utero and lactational exposure to perfluorooctanoic acid.Archives of toxicology · 2016Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
The estrogenic and antiestrogenic potential of perfluorooctanoic acid (PFOA) was assessed using an immature mouse uterotrophic assay and by histologic evaluation of the uterus, cervix and vagina following treatment. Female offspring of CD-1 dams were weaned at 18days old and assigned to groups of equal weight, and received 0, 0.01, 0.1, or 1mg PFOA/kg BW/d by gavage with or without 17-β estradiol (E(2), 500μg/kg/d) from PND 18-20 (n=8/treatment/block). At 24h after the third dose (PND 21), uteri were removed and weighed. Absolute and relative uterine weights were significantly increased in the 0.01mg/kg PFOA only group. Characteristic estrogenic changes were present in all E(2)-treated mice; however, they were minimally visible in the 0.01 PFOA only mice. These data suggest that at a low dose PFOA produces minimal histopathologic changes in the reproductive tract of immature female mice, and does not antagonize the histopathologic effects of E(2).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.