Evidence map›Paper›PMID 22146193›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2012

Delayed cerebral ischemia and spreading depolarization in absence of angiographic vasospasm after subarachnoid hemorrhage.

Johannes Woitzik, Jens P Dreier, Nils Hecht, Ingo Fiss, Nora Sandow, Sebastian Major, Maren Winkler, Yuliya A Dahlem, Jerome Manville, Michael Diepers and 5 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04507295 (the Effect of Different Modes of Mechanical Ventilation on Cerebral Blood Flow During Thoracoscopic Surgeries in Neonates), which is not on this map. Cited by 97 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 5 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04507295 naunknown statusnot on this mapstarted 2020, after this paper: background citation

the Effect of Different Modes of Mechanical Ventilation on Cerebral Blood Flow During Thoracoscopic Surgeries in Neonates (RCT)

TypeinterventionalSponsorCairo UniversityRan2020 to 2020Enrolled30ConditionsTracheo Esophageal Fistula, Congenital Diaphragmatic HerniaArmscerebral oximetry ( INVOS 5100 )
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 5 syntheses or guidelines pooled it, 187 citations in OpenAlex.

  1. Pooled it
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  3. Systematic review of the pharmacological agents that have been tested against spreading depolarizations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Pooled it
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  6. Trial
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  13. Observational
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  20. Pathophysiology, Management, and Therapeutics in Subarachnoid Hemorrhage and Delayed Cerebral Ischemia: An Overview.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023
    Review

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Johannes WoitzikDepartment of Neurosurgery, Charité-Universitätsmedizin Berlin, Berlin, Germany. johannes.woitzik@charite.de
Jens P Dreier
Nils Hecht
Ingo Fiss
Nora Sandow
Sebastian Major
Maren Winkler
Yuliya A Dahlem
Jerome Manville
Michael Diepers
Elke Muench
Hidetoshi Kasuya
Peter Schmiedek
Peter Vajkoczy
COSBID study group
Charité - Universitätsmedizin Berlin · DEUniversity of Mannheim · DEHeidelberg University · DETokyo Women's Medical University Adachi Medical Center · JPUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been hypothesized that vasospasm is the prime mechanism of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Recently, it was found that clusters of spreading depolarizations (SDs) are associated with DCI. Surgical placement of nicardipine prolonged-release implants (NPRIs) was shown to strongly attenuate vasospasm. In the present study, we tested whether SDs and DCI are abolished when vasospasm is reduced or abolished by NPRIs. After aneurysm clipping, 10 NPRIs were placed next to the proximal intracranial vessels. The SDs were recorded using a subdural electrode strip. Proximal vasospasm was assessed by digital subtraction angiography (DSA). 534 SDs were recorded in 10 of 13 patients (77%). Digital subtraction angiography revealed no vasospasm in 8 of 13 patients (62%) and only mild or moderate vasospasm in the remaining. Five patients developed DCI associated with clusters of SD despite the absence of angiographic vasospasm in three of those patients. The number of SDs correlated significantly with the development of DCI. This may explain why reduction of angiographic vasospasm alone has not been sufficient to improve outcome in some clinical studies.

Indexed as

AdultAgedAngiography, Digital SubtractionAntihypertensive AgentsBrainBrain IschemiaCortical Spreading DepressionFemaleHumansMaleMiddle AgedNicardipineProspective StudiesProstheses and ImplantsSubarachnoid HemorrhageVasospasm, IntracranialAntihypertensive AgentsNicardipine

Identifiers

PMID22146193
PMCPMC3272613
OpenAlexW1981291188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.