ArticleAnalytical chemistry2012
Silica coated paper substrate for paper-spray analysis of therapeutic drugs in dried blood spots.
Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 197 citations in OpenAlex.
- Article
- Miniature mass spectrometer-based point-of-care assay for measuring three psychiatric drugs in human plasma and whole blood.Analytical and bioanalytical chemistry · 2025Article
- Analysis of Drugs in Whole Blood by Paper Spray Mass Spectrometry with Integrated Solid-Phase Extraction.Analytical chemistry · 2025Article
- Identification and Mitigation of Pyrolysis Products in Laser-Cut Paper for Paper Spray Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2025Article
- Performance Comparison of Liquid Chromatography and Paper Spray Ionization with Mass Spectrometry for Measuring Kinase Inhibitors in Human Plasma.ACS pharmacology & translational science · 2025Article
- Plasma drug screening using paper spray mass spectrometry with integrated solid phase extraction.Drug testing and analysis · 2025Article
- Paper Spray Mass Spectrometry with On-Paper Electrokinetic Manipulations: Part-Per-Trillion Detection of Per/Polyfluoroalkyl Substances in Water and Opioids in Urine.Angewandte Chemie (International ed. in English) · 2024Article
- [Development of an analytical system for dried blood spots for forensic toxicology: a case study of five common drugs and poisons].Se pu = Chinese journal of chromatography · 2024Article
- Assessing the Effectiveness of Chemical Marker Extraction from Amazonian Plant Cupuassu (Metabolites · 2023Article
- Portable mass spectrometry system: instrumentation, applications, and path to 'omics analysis.Proteomics · 2022Review
- Miniature mass spectrometer-based point-of-care assay for cabotegravir and rilpivirine in whole blood.Analytical and bioanalytical chemistry · 2022Article
- Recent advances in on-site mass spectrometry analysis for clinical applications.Trends in analytical chemistry : TRAC · 2022Review
- Protective mechanism of dried blood spheroids: stabilization of labile analytes in whole blood, plasma, and serum.The Analyst · 2021Article
- In Situ Separation and Analysis of Lipids by Paper Spray Ionization Mass Spectrometry.Molecules (Basel, Switzerland) · 2020Article
- Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications.Mass spectrometry reviews · 2020Review
- Nanomaterial-Modified Conducting Paper: Fabrication, Properties, and Emerging Biomedical Applications.Global challenges (Hoboken, NJ) · 2019Review
- Paper spray screening and liquid chromatography/mass spectrometry confirmation for medication adherence testing: A two-step process.Rapid communications in mass spectrometry : RCM · 2019Article
- Molecularly imprinted graphite spray ionization-ion mobility spectrometry: application to trace analysis of the pesticide propoxur.Mikrochimica acta · 2019Article
- Direct sampling mass spectrometry for clinical analysis.The Analyst · 2019Review
- Reinventing (Bio)chemical Analysis with Paper.Analytical chemistry · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Paper spray is a newly developed ambient ionization method that has been applied for direct qualitative and quantitative analysis of biological samples. The properties of the paper substrate and spray solution have a significant impact on the release of chemical compounds from complex sample matrices, the diffusion of the analytes through the substrate, and the formation of ions for mass spectrometry analysis. In this study, a commercially available silica-coated paper was explored in an attempt to improve the analysis of therapeutic drugs in dried blood spots (DBS). The dichloromethane/isopropanol solvent has been identified as an optimal spray solvent for the analysis. The comparison was made with paper spray using chromatography paper as substrate with methanol/water as solvent for the analysis of verapamil, citalopram, amitriptyline, lidocaine, and sunitinib in dried blood spots. It has been demonstrated that the efficiency of recovery of the analytes was notably improved with the silica coated paper and the limit of quantitation (LOQ) for the drug analysis was 0.1 ng mL(-1) using a commercial triple quadrupole mass spectrometer. The use of silica paper substrate also resulted in a sensitivity improvement of 5-50-fold in comparison with chromatography papers, including the Whatman ET31 paper used for blood cards. Analysis using a hand-held miniature mass spectrometer Mini 11 gave LOQs of 10-20 ng mL(-1) for the tested drugs, which is sufficient to cover the therapeutic ranges of these drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.