Evidence map›Paper›PMID 22145095›Full record

ArticleSmall GTPases2011

A Rab-based view of membrane traffic in the ciliate Tetrahymena thermophila.

Aaron P Turkewitz, Lydia J Bright

Open access · hybridAbstract read
In one paragraph

Article in Small GTPases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aaron P TurkewitzDept. of Molecular Genetics and Cell Biology; The University of Chicago; Chicago IL USA.
Lydia J Bright
University of Chicago · US

Funding

PREDOCTORAL TRAINING IN GENETICS AND REGULATIONT32GM007197 · NIGMS · UNIVERSITY OF CHICAGO · PI ROTHMAN-DENES, LUCIA B. B · 1985 to 2020
$17.0M
Biogenesis of Dense Core Secretory Granules in TetrahymenaR01GM077607 · NIGMS · UNIVERSITY OF CHICAGO · PI TURKEWITZ, AARON P · 2006 to 2009
$1.1M
NIGMS NIH HHS R01 GM077607NIGMS NIH HHS T32 GM007197
6 · The paper itself

Abstract

Biologists have long recognized that some single-celled organisms show striking morphological and behavioral complexity, and details of the genetic underpinnings can be mined from the trove of newly-sequenced genomes. Ciliates, among which Tetrahymena thermophila and Paramecium tetraurelia have received most attention, provide clear examples of a lineage in which, as in animal cells, the core pathways of membrane traffic have undergone dramatic expansion and elaboration to facilitate multiple modes of exocytosis and endocytosis. Recent surveys of the Rab GTPases in T. thermophila, including analysis of a large set of GFP-tagged copies, provide a new set of compartmental markers for this lineage, as well as striking views of membrane dynamics in these cells. In addition, phylogenetic analysis of the Tetrahymena Rabs suggests that different eukaryotic lineages may have independently evolved some functionally similar pathways.

Identifiers

PMID22145095
PMCPMC3225912
OpenAlexW1971880498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.