ReviewExperimental diabetes research2011
Fetoplacental vascular endothelial dysfunction as an early phenomenon in the programming of human adult diseases in subjects born from gestational diabetes mellitus or obesity in pregnancy.
Review in Experimental diabetes research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05091827 (Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in Utero), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in Utero
Who cites it
22 citing papers in PubMed, 68 citations in OpenAlex.
- Subclinical Changes in Cardiovascular Function During the Neonatal Period in Infants Born to Mothers With Diabetes.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Transcription Factor EB (TFEB) Expression and Localization in the Third-Trimester Placenta.International journal of molecular sciences · 2025Article
- Bioinformatic identification of signature miRNAs associated with fetoplacental vascular dysfunction in gestational diabetes mellitus.Biochemistry and biophysics reports · 2025Article
- Plasma Redox Balance in Advanced-Maternal-Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells.International journal of molecular sciences · 2024Article
- Gestational Diabetes-Placental Expression of Human Equilibrative Nucleoside Transporter 1 (hENT1): Is Delayed Villous Maturation an Adaptive Pattern?Diagnostics (Basel, Switzerland) · 2023Article
- Gestational Diabetes Mellitus and Energy-Dense Diet: What Is the Role of the Insulin/IGF Axis?Frontiers in endocrinology · 2022Review
- Assessment of the impact of HIV infection and anti-retroviral treatment on the cardiometabolic health of pregnant mothers and their offspring (ARTMOMSBABES).BMC cardiovascular disorders · 2021Article
- Vitamin D status and vitamin D deficiency risk factors among pregnancy of Shanghai in China.BMC pregnancy and childbirth · 2021Article
- Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsiaFrontiers in cardiovascular medicine · 2021Article
- Maternal Predictors of Disparate Outcomes in Children With Single Ventricle Congenital Heart Disease.Journal of the American Heart Association · 2020Observational
- Early pregnancy prediction of gestational diabetes mellitus risk using prenatal screening biomarkers in nulliparous women.Diabetes research and clinical practice · 2020Article
- Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?Frontiers in endocrinology · 2020Review
- Developmental onset of cardiovascular disease-Could the proof be in the placenta?Microcirculation (New York, N.Y. : 1994) · 2019Review
- Hyperglycaemia cause vascular inflammation through advanced glycation end products/early growth response-1 axis in gestational diabetes mellitus.Molecular and cellular biochemistry · 2019Article
- Streptozotocin‑induced diabetic mice exhibit reduced experimental choroidal neovascularization but not corneal neovascularization.Molecular medicine reports · 2018Article
- Pre-, Perinatal, and Parental Predictors of Body Mass Index Trajectory Milestones.The Journal of pediatrics · 2018Article
- Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia.Oxidative medicine and cellular longevity · 2015Review
- Diseases of pregnancy and fetal programming: cell and molecular mechanisms.BioMed research international · 2014Article
- Modulation of endothelial cell migration by ER stress and insulin resistance: a role during maternal obesity?Frontiers in pharmacology · 2014Review
- Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results.Lipids in health and disease · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gestational diabetes mellitus (GDM) and obesity in pregnancy (OP) are pathological conditions associated with placenta vascular dysfunction coursing with metabolic changes at the fetoplacental microvascular and macrovascular endothelium. These alterations are seen as abnormal expression and activity of the cationic amino acid transporters and endothelial nitric oxide synthase isoform, that is, the "endothelial L-arginine/nitric oxide signalling pathway." Several studies suggest that the endogenous nucleoside adenosine along with insulin, and potentially arginases, are factors involved in GDM-, but much less information regards their role in OP-associated placental vascular alterations. There is convincing evidence that GDM and OP prone placental endothelium to an "altered metabolic state" leading to fetal programming evidenced at birth, a phenomenon associated with future development of chronic diseases. In this paper it is suggested that this pathological state could be considered as a metabolic marker that could predict occurrence of diseases in adulthood, such as cardiovascular disease, obesity, diabetes mellitus (including gestational diabetes), and metabolic syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.