ArticleFrontiers in integrative neuroscience2011
Adaptive timing of motor output in the mouse: the role of movement oscillations in eyelid conditioning.
Article in Frontiers in integrative neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Unsupervised nonmotor learning in the human cerebellum.bioRxiv : the preprint server for biology · 2026Article
- The Human Cerebellum Encodes Temporally Sensitive Reinforcement Learning Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Impact of Sema3A Interference on Cerebellum-Dependent Motor Associative Learning and Memory.International journal of molecular sciences · 2026Article
- The human cerebellum encodes temporally sensitive reinforcement learning signals.bioRxiv : the preprint server for biology · 2025Article
- Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.Nature communications · 2025Article
- High-resolution awake mouse fMRI at 14 tesla.eLife · 2025Article
- High-resolution awake mouse fMRI at 14 Tesla.bioRxiv : the preprint server for biology · 2024Article
- Climbing fibers provide essential instructive signals for associative learning.Nature neuroscience · 2024Article
- Impact of enriched environment on motor performance and learning in mice.Scientific reports · 2024Article
- Discrimination training affects stimulus generalization in mice during Pavlovian eyeblink conditioning.Frontiers in behavioral neuroscience · 2024Article
- Synaptic mechanisms for associative learning in the cerebellar nuclei.Nature communications · 2023Article
- A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning.Journal of visualized experiments : JoVE · 2022Article
- Young Domestic PigsFrontiers in behavioral neuroscience · 2021Article
- A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells.PloS one · 2021Article
- Cannabinoids modulate associative cerebellar learning via alterations in behavioral state.eLife · 2020Article
- Stress and behavioral correlates in the head-fixed method: stress measurements, habituation dynamics, locomotion, and motor-skill learning in mice.Scientific reports · 2020Article
- SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.PLoS biology · 2020Article
- Delayed Complex Spike Response Evoked by Conditioned Stimulus Encodes Movement Onset Time and Is Determined by Intrinsic Inferior Olive Properties.Frontiers in systems neuroscience · 2019Article
- Impact of parallel fiber to Purkinje cell long-term depression is unmasked in absence of inhibitory input.Science advances · 2018Article
- Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions.Nature neuroscience · 2018Article
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4 authors.
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Abstract
To survive, animals must learn to control their movements with millisecond-level precision, and adjust the kinematics if conditions, or task requirements, change. Here, we examine adaptive timing of motor output in mice, using a simple eyelid conditioning task. Mice were trained to blink in response to a light stimulus that was always followed by a corneal air-puff at a constant time interval. Different mice were trained with different intervals of time separating the onset of the light and the air-puff. As in previous work in other animal species, mice learned to control the speed of the blink, such that the time of maximum eyelid closure matched the interval used during training. However, we found that the time of maximum eyelid speed was always in the first 100 ms after movement onset and did not scale with the training interval, indicating that adaptive timing is not accomplished by slowing down (or speeding up) the eyelid movement uniformly throughout the duration of the blink. A new analysis, specifically designed to examine the kinematics of blinks in single trials, revealed that the underlying control signal responsible for the eyelid movement is made up of oscillatory bursts that are time-locked to the light stimulus at the beginning of the blink, becoming desynchronized later on. Furthermore, mice learn to blink at different speeds and time the movement appropriately by adjusting the amplitude, but not the frequency of the bursts in the eyelid oscillation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.